there is no clean conversion between the two, anyone giving you a ratio is guessing
#tirzepatide 2025-08-06
Wednesday44 messages11 participantstimes are UTC
Highlights from this day
- lean_mass_lex — changed my mind about needing 15, i was chasing a number rather than an outcome, for what its worth 16:47
- lean_mass_lex — the two compounds arent interchangeable week for week even if the effect ends up similar 17:15
- vialkeeper — the sweet spot argument is really about effect per side effect, not a magic number 17:41
- swab_dry_first — SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up, anyway 18:10
- nausea_window — how many weeks at 7.5 before you knew it was enough 21:01
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
changed my mind about needing 15, i was chasing a number rather than an outcome, for what its worth
👍7📉6👀4
15 is the top
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
switched last year
no clean conversion
🙏10
the two compounds arent interchangeable week for week even if the effect ends up similar
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)SURMOUNT-1 versus SURPASS-2, which one was the weight trial
if youre coming off semaglutide the honest answer is start low and find out, theres no table
folklore probably
my Medutest result on a GL Biochem vial came in at 97.4 which is why i keep buying from them
anyone got a 4 recon they like for the 40 vials
whats the top licensed dose, 15 or does it go higher
the sweet spot argument is really about effect per side effect, not a magic number
💀11✅17👍12
did going from 1 semaglutide to 5 of this feel like a step down for anyone
genuine question is SURMOUNT-OSA the sleep apnoea one
is the sweet spot argument about effect or about side effects
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up, anyway
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i argued the sweet spot was nonsense and then spent 18 months at 7.5 not needing more
easier gi for me
the trials titrated every four weeks to a target, most people here stop at whatever works
unrelated but plateaued at 23 weeks the same way i did on semaglutide, so i doubt its compound specific
the switch felt like a step down at first and then caught up around week 20
at 0.5 my appetite is gone entirely, did anyone go down rather than up
7.5 gang
does the GIP arm actually explain the easier nausea or is that hand waving
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
right so im at 12 and thinking about 1.7, did anyone gain anything from that step
is the 5 vial the common one or do people use 2
10 was enough
👍1💀1❤️1
titrate slow
😂5🧊1
the 2.5 to 5 step was the roughest one for me and everything after was easier
went back to semaglutide after 21 months because the cost difference mattered more than the GI
[edited]whats the plateau pattern here, same as semaglutide or different
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
i went to 15 and came back to 10, more suppression wasnt more useful for me
how long before the dual thing was noticeable to you
the sweet spot thing is survivorship, the people it worked for stayed and said so
5 did nothing
medutest-report-a-2418.pdf
3 pages · 585 KB · not retained in the public archive
SURMOUNT is weight
does the appetite effect feel different or just stronger
how many weeks at 7.5 before you knew it was enough
does switching from semaglutide need a gap or do you just start
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