GIP plus GLP-1
#tirzepatide 2025-09-12
Friday57 messages11 participantstimes are UTC
Highlights from this day
- seoul_swirl — 5 was where i first noticed it properly, 2.5 did almost nothing for me 16:21
- cold_chain_cmdr — how long before the dual thing was noticeable to you 17:11
- peak_split — switched from 0.25 semaglutide and started at 2.5, took the slow route, never regretted it 19:47
- identity_shift — whats the top licensed dose, 15 or does it go higher 20:45
at 15 the GI came back for me, so my easier profile claim only applies below that, someone check my working
switched from 1 semaglutide and started at 2.5, took the slow route, never regretted it
why does everyone talk about 7.5 and not 10
switched from 1.7 semaglutide and started at 2.5, took the slow route, never regretted it
Verification log updated: HJ — evidence added, status unchanged.
ok so the switch felt like a step down at first and then caught up around week 9
is there a reason to titrate slower than the four week schedule
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coming back to this did anyone go past 15 and was there any point to it
if youre coming off semaglutide the honest answer is start low and find out, theres no table
went back to semaglutide after 1 months because the cost difference mattered more than the GI
5 was where i first noticed it properly, 2.5 did almost nothing for me
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£72 for a 40 vial is roughly what ive paid for the last year, ymmv
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
anyone tracked whether the GI difference held at the top doses
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
while im here the GI difference held for me right up to 15, which isnt what a couple of people here found
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anyone stopped at 10 and stayed there for months
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
how did people handle the 2.5 to 5 jump
the two compounds arent interchangeable week for week even if the effect ends up similar
my PeptideMeter result on a HJ vial came in at 99 which is why i keep buying from them, take that with a pinch of salt
how long before the dual thing was noticeable to you
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the trials titrated every four weeks to a target, most people here stop at whatever works
5 was where i first noticed it properly, 2.5 did almost nothing for me
i argued the sweet spot was nonsense and then spent 26 months at 7.5 not needing more
coming back to this anyone got a 10 recon they like for the 15 vials
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SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
checked the units twice
7.5 gang
changed my mind about needing 15, i was chasing a number rather than an outcome
whats the plateau pattern here, same as semaglutide or different
12 did nothing extra over 10 for me and that still holds a year later
switched last year
did going from 0.25 semaglutide to 5 of this feel like a step down for anyone
[edited]at 0.25 my appetite went completely and i dropped back a step, eating nothing isnt a win
does the appetite effect feel different or just stronger
15 is the top
titrate slow
Channel stats, last 30 days: 53 messages from 41 members.
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did anybody switch back to semaglutide after trying this
SURMOUNT is weight
does the GIP arm actually explain the easier nausea or is that hand waving
restarted at 2.5 after 6 months off and the first two doses reminded me why titration exists, happy to be corrected
no gap when i switched, took the last semaglutide dose and started this a week later, i have it written down somewhere
held 10 for 10 months and lost 30kg over that stretch, slow and boring and fine
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same plateau here
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folklore probably
is 7.5 really the sweet spot or is that just channel folklore
5 did nothing
is SURMOUNT-OSA the sleep apnoea one
switched from 0.25 semaglutide and started at 2.5, took the slow route, never regretted it
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does switching from semaglutide need a gap or do you just start
coming off semaglutide, is there a conversion or do i restart at 2.5
the 40 vial in 2ml gives 4mg/ml which puts 15 on 12 units, nice round numbers
the sweet spot thing is survivorship, the people it worked for stayed and said so, not advice obviously
unrelated but SURMOUNT-1 versus SURPASS-2, which one was the weight trial
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Verification log updated: JEEP — evidence added, status unchanged.
there is no clean conversion between the two, anyone giving you a ratio is guessing
whats the top licensed dose, 15 or does it go higher
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is the 15 vial the common one or do people use 30
the 2.5 to 5 step was the roughest one for me and everything after was easier