is the sweet spot argument about effect or about side effects
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
genuine question i sat at 7.5 for 16 months and never needed more, which is where the folklore comes from
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
is there a reason to titrate slower than the four week schedule
i argued the sweet spot was nonsense and then spent 9 months at 7.5 not needing more
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up, take that with a pinch of salt
titrate slow
how long before the dual thing was noticeable to you
[edited]at 5 my appetite went completely and i dropped back a step, eating nothing isnt a win
15 is the top
back after 21 months, do i restart at 2.5 or pick up near where i left off
[edited]12 did nothing extra over 10 for me and that still holds a year later
40 units of a 8 solution is a lot of volume and i check that one twice every single time
start low anyway
my Janoshik result on a TFC vial came in at 99 which is why i keep buying from them
checked the units twice
€55 for a 20 vial is roughly what ive paid for the last year
restarted at 2.5 after 17 months off and the first two doses reminded me why titration exists
whats the top licensed dose, 15 or does it go higher
5 did nothing
switched last year
update on the earlier thing i log everything and my appetite curve looks flatter across the week than my semaglutide log did
unrelated but no gap when i switched, took the last semaglutide dose and started this a week later
right so does the appetite effect feel different or just stronger
im at 5 and thinking about 12, did anyone gain anything from that step
held 10 for 16 months and lost 36kg over that stretch, slow and boring and fine
follow up there is no clean conversion between the two, anyone giving you a ratio is guessing
[edited]right so does the GIP arm actually explain the easier nausea or is that hand waving
changed my mind about needing 15, i was chasing a number rather than an outcome
follow up did anyone find the GI easier than semaglutide at an equivalent effect
coming off semaglutide, is there a conversion or do i restart at 2.5
anyone stopped at 10 and stayed there for months
at 15 the GI came back for me, so my easier profile claim only applies below that
i went to 15 and came back to 10, more suppression wasnt more useful for me
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does, ymmv
right so at 1 my appetite is gone entirely, did anyone go down rather than up
Recon calculator: 2mg in 5ml = 5mg/ml.
why does everyone talk about 7.5 and not 10
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
update on the earlier thing went back to semaglutide after 1 months because the cost difference mattered more than the GI
ok so is 7.5 really the sweet spot or is that just channel folklore
the 2.5 to 5 step was the roughest one for me and everything after was easier
the sweet spot thing is survivorship, the people it worked for stayed and said so
the sweet spot thing is survivorship, the people it worked for stayed and said so
the GI difference held for me right up to 15, which isnt what a couple of people here found
[edited]SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
is the 15 vial the common one or do people use 40
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
the trials titrated every four weeks to a target, most people here stop at whatever works
if youre coming off semaglutide the honest answer is start low and find out, theres no table