licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does, i could be wrong
#tirzepatide 2025-09-14
Sunday65 messages14 participantstimes are UTC
Highlights from this day
- thank_you_year_on — is the 20 vial the common one or do people use 15 22:14
- VialBot — Verification log updated: JEEP — evidence added, status unchanged. 22:22
- new_here_nat — dual agonist, GIP as well as GLP-1, thats the whole difference in one line 22:44
- tam_logs — the sweet spot argument is really about effect per side effect, not a magic number 23:01
- swab_dry_first — i sat at 7.5 for 23 months and never needed more, which is where the folklore comes from 23:23
the two compounds arent interchangeable week for week even if the effect ends up similar
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changed my mind about needing 15, i was chasing a number rather than an outcome
same plateau here
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i argued the sweet spot was nonsense and then spent 18 months at 7.5 not needing more
how did people handle the 2.5 to 5 jump
40 units of a 5 solution is a lot of volume and i check that one twice every single time
whats the top licensed dose, 15 or does it go higher
while im here how long before the dual thing was noticeable to you
12 did nothing extra over 10 for me and that still holds a year later
switched last year
5 was where i first noticed it properly, 2.5 did almost nothing for me
plateaued at 28 weeks the same way i did on semaglutide, so i doubt its compound specific
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
my PeptideMeter result on a KP vial came in at 97.4 which is why i keep buying from them, ill dig out the number
15 is the top
went back to semaglutide after 7 months because the cost difference mattered more than the GI
im at 2.4 and thinking about 2, did anyone gain anything from that step
does the appetite effect feel different or just stronger
[edited]the sweet spot thing is survivorship, the people it worked for stayed and said so
is SURMOUNT-OSA the sleep apnoea one
[edited]is the 20 vial the common one or do people use 15
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)does the GIP arm actually explain the easier nausea or is that hand waving
how many weeks at 7.5 before you knew it was enough
unrelated but coming off semaglutide, is there a conversion or do i restart at 2.5
*Medutest not the other one
Verification log updated: JEEP — evidence added, status unchanged.
genuine question at 5 my appetite went completely and i dropped back a step, eating nothing isnt a win
7.5 gang
at 15 the GI came back for me, so my easier profile claim only applies below that
does switching from semaglutide need a gap or do you just start
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up, thats one data point
coming back to this did anyone find the GI easier than semaglutide at an equivalent effect
the trials titrated every four weeks to a target, most people here stop at whatever works
folklore probably
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
checked the units twice
GIP plus GLP-1
back after 5 months, do i restart at 2.5 or pick up near where i left off
SURMOUNT is weight
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
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no clean conversion
i went to 15 and came back to 10, more suppression wasnt more useful for me
start low anyway
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
is 7.5 really the sweet spot or is that just channel folklore
no gap when i switched, took the last semaglutide dose and started this a week later
the sweet spot argument is really about effect per side effect, not a magic number
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genuine question did anybody switch back to semaglutide after trying this
there is no clean conversion between the two, anyone giving you a ratio is guessing
did going from 2.4 semaglutide to 5 of this feel like a step down for anyone
whats the plateau pattern here, same as semaglutide or different
the switch felt like a step down at first and then caught up around week 28
is there a reason to titrate slower than the four week schedule
fridge-temps.csv
307 rows · not retained in the public archive
easier gi for me
titrate slow
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
i sat at 7.5 for 23 months and never needed more, which is where the folklore comes from
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
if youre coming off semaglutide the honest answer is start low and find out, theres no table
£55 for a 15 vial is roughly what ive paid for the last year
10 was enough
the GI difference held for me right up to 15, which isnt what a couple of people here found
anyone stopped at 10 and stayed there for months
did anyone go past 15 and was there any point to it
if youre coming off semaglutide the honest answer is start low and find out, theres no table
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
the 15 vial in 1ml gives 4mg/ml which puts 1.7 on 8 units, nice round numbers