i argued the sweet spot was nonsense and then spent 21 months at 7.5 not needing more, happy to be corrected
#tirzepatide 2025-09-15
Monday44 messages8 participantstimes are UTC
Highlights from this day
- power_through_no — i sat at 7.5 for 19 months and never needed more, which is where the folklore comes from 17:00
- HPLC_Hank — the GI difference held for me right up to 15, which isnt what a couple of people here found i argued the sweet spot was nonsense and then spent 17 months at 7.5 not… 17:02
- VialBot — Assay note: QST lot H-2814 reported at 98.6% of label content. 18:12
- dublin_dose — held 10 for 5 months and lost 46kg over that stretch, slow and boring and fine 18:23
- lisbon_lot — does the GIP arm actually explain the easier nausea or is that hand waving switched from 2 semaglutide and started at 2.5, took the slow route, never regretted it 18:29
titrate slow
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
start low anyway
easier gi for me
nine_nine_onei argued the sweet spot was nonsense and then spent 21 months at 7.5 not needing more,…
at 2 my appetite is gone entirely, did anyone go down rather than up
[edited]ok so back after 11 months, do i restart at 2.5 or pick up near where i left off
unrelated but $240 for a 20 vial is roughly what ive paid for the last year
[edited]for the archive im at 2 and thinking about 2.4, did anyone gain anything from that step
same plateau here
changed my mind about needing 15, i was chasing a number rather than an outcome
SURMOUNT is weight
plateaued at 33 weeks the same way i did on semaglutide, so i doubt its compound specific
switched last year
transit-times.csv
359 rows · not retained in the public archive
the 30 vial in 1.5ml gives 2.5mg/ml which puts 7.5 on 10 units, nice round numbers, happy to be corrected
checked the units twice
restarted at 2.5 after 7 months off and the first two doses reminded me why titration exists
i sat at 7.5 for 19 months and never needed more, which is where the folklore comes from
🎉2📉8
the GI difference held for me right up to 15, which isnt what a couple of people here found
i argued the sweet spot was nonsense and then spent 17 months at 7.5 not needing more
⚠️1📈16🙏18
for the archive at 15 the GI came back for me, so my easier profile claim only applies below that, thats one data point
folklore probably
update on the earlier thing is 7.5 really the sweet spot or is that just channel folklore
no clean conversion
🧪5
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
no gap when i switched, took the last semaglutide dose and started this a week later
[redacted at member request] · archive policy
did anybody switch back to semaglutide after trying this
15 is the top
10 was enough
the 2.5 to 5 step was the roughest one for me and everything after was easier
did anyone go past 15 and was there any point to it
40 units of a 10 solution is a lot of volume and i check that one twice every single time
switched from 0.5 semaglutide and started at 2.5, took the slow route, never regretted it
the sweet spot thing is survivorship, the people it worked for stayed and said so
Assay note: QST lot H-2814 reported at 98.6% of label content.
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the sweet spot argument is really about effect per side effect, not a magic number
5 did nothing
i went to 15 and came back to 10, more suppression wasnt more useful for me
held 10 for 5 months and lost 46kg over that stretch, slow and boring and fine
😂10
at 2.5 my appetite went completely and i dropped back a step, eating nothing isnt a win
anyone tracked whether the GI difference held at the top doses
[edited]there is no clean conversion between the two, anyone giving you a ratio is guessing
does the GIP arm actually explain the easier nausea or is that hand waving
switched from 2 semaglutide and started at 2.5, took the slow route, never regretted it
janoshik-h-2814.pdf
2 pages · 280 KB · not retained in the public archive