15 is the top
#tirzepatide 2025-09-16
Tuesday54 messages10 participantstimes are UTC
Highlights from this day
- blank_run — the ladder is a ceiling on how fast you may go, not a schedule you owe anyone 10:37
- bengaluru_bac — for anyone drawing from vials, the maths at each step 11:08
- batch_bandit — always trade volume for readability. always 11:20
- bengaluru_bac — their paperwork if anyone wants to argue with it in #coa-reading 11:30
- VialBot — dose reminder for @bengaluru_bac: 5 mg due today, week 3 of 4 at this step. next scheduled review 2 weeks. 12:41
is there a reason to titrate slower than the four week schedule
im at 0.5 and thinking about 1, did anyone gain anything from that step
did anyone find the GI easier than semaglutide at an equivalent effect
09:03marrow.mod pinned a message
the 2 vial in 1.5ml gives 5mg/ml which puts 2.4 on 30 units, nice round numbers
my Medutest result on a JEEP vial came in at 99.2 which is why i keep buying from them
10 was enough
⚠️9🎉8🙏17
easier gi for me
right so i went to 15 and came back to 10, more suppression wasnt more useful for me
whats the standard tirz ladder. i keep seeing different versions
label version is 2.5 for four weeks then 5, then 4 week steps of 2.5 up to whatever you stop at
| Weeks | Dose | Note |
|---|---|---|
| 1–4 | 2.5 mg | starter, not a therapeutic dose |
| 5–8 | 5 mg | first real dose |
| 9–12 | 7.5 mg | where a lot of people stop |
| 13–16 | 10 mg | |
| 17–20 | 12.5 mg | |
| 21+ | 15 mg | top studied dose |
so 5 months to top dose
if you go straight up with no holds, yes. almost nobody goes straight up with no holds
i took eleven months and stopped at 10
im at 5 and honestly not in a hurry, its working
the ladder is a ceiling on how fast you may go, not a schedule you owe anyone
✅9
but the trial results are at 15
the trial means are reported by assigned arm. plenty of people in the 15mg arm spent large stretches at reduced doses
the arm label and what went into the person are not the same thing
that is genuinely the most useful thing ive read this week
🧠7
for anyone drawing from vials, the maths at each step
30mg in 1.5ml -> 20mg/ml
2.5mg = 0.125ml = 12.5 units (u100)
5.0mg = 0.25ml = 25 units
7.5mg = 0.375ml = 37.5 units
10mg = 0.5ml = 50 units
12.5mg = 0.625ml = 62.5 units
15mg = 0.75ml = 75 units
half units on a u100 pin are guesswork. if you live at
7.5 or 12.5 use a weaker recon so you land on whole units.how much weaker
i do 30mg in 3ml = 10mg/ml. then 7.5mg is 0.75ml = 75 units, dead on a line
bigger volume to inject but you can actually see what you drew
always trade volume for readability. always
✅11📐3
does the bigger volume sting
0.75ml subcut is fine. slow push. theres a whole conversation about this in #injection-technique
the Qingdao Saber lots ive used reconstitute clean at 10mg/ml, no haze
their paperwork if anyone wants to argue with it in #coa-reading
qst-tirz-lot-b9082-coa.pdf
3 pages · 410 KB · not retained in the public archive
content assay is the column to look at there, not the purity one. read it before you quote it
wait why would purity not be the important one
purity tells you what fraction of the peptide present is the right peptide. content tells you how much peptide is in the vial at all
99% pure and 60% of label content is a real and fairly common failure mode
ok that reframes everything
😳8
dose reminder for @bengaluru_bac: 5 mg due today, week 3 of 4 at this step. next scheduled review 2 weeks.
the bot knows my ladder better than i do
back to the five months thing — is there any harm in going slower than the label
not that anyone has shown. you spend longer at lower exposure, which mostly means slower loss and fewer bad weeks
eleven months and i lost the same total as friends who rushed it. i just enjoyed it more
right so at 0.5 my appetite is gone entirely, did anyone go down rather than up
titrate slow
does switching from semaglutide need a gap or do you just start
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
transit-times.csv
716 rows · not retained in the public archive
restarted at 2.5 after 3 months off and the first two doses reminded me why titration exists
the switch felt like a step down at first and then caught up around week 14
at 15 the GI came back for me, so my easier profile claim only applies below that
i argued the sweet spot was nonsense and then spent 4 months at 7.5 not needing more, for what its worth
coming off semaglutide, is there a conversion or do i restart at 2.5
i went to 15 and came back to 10, more suppression wasnt more useful for me
no gap when i switched, took the last semaglutide dose and started this a week later
*week 21 not week 8
13:52marrow.mod pinned a message
did anyone go past 15 and was there any point to it
start low anyway