at 15 the GI came back for me, so my easier profile claim only applies below that
#tirzepatide 2025-09-20
Saturday58 messages12 participantstimes are UTC
Highlights from this day
- oli_orals — held 10 for 6 months and lost 43kg over that stretch, slow and boring and fine, your mileage will differ 06:12
- cold_chain_cmdr — the 2.5 to 5 step was the roughest one for me and everything after was easier 06:32
- fasting_insulin — did anybody switch back to semaglutide after trying this 06:45
12 did nothing extra over 10 for me and that still holds a year later
for the archive went back to semaglutide after 4 months because the cost difference mattered more than the GI
15 is the top
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
the switch felt like a step down at first and then caught up around week 8, ill dig out the number
held 10 for 6 months and lost 43kg over that stretch, slow and boring and fine, your mileage will differ
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anyone stopped at 10 and stayed there for months
10 was enough
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5 did nothing
restarted at 2.5 after 10 months off and the first two doses reminded me why titration exists
i sat at 7.5 for 18 months and never needed more, which is where the folklore comes from
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
the 2.5 to 5 step was the roughest one for me and everything after was easier
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my VendorInvestigate result on a SGN vial came in at 99.2 which is why i keep buying from them
same plateau here
does the appetite effect feel different or just stronger
did anybody switch back to semaglutide after trying this
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there is no clean conversion between the two, anyone giving you a ratio is guessing, from memory
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plateaued at 8 weeks the same way i did on semaglutide, so i doubt its compound specific
if youre coming off semaglutide the honest answer is start low and find out, theres no table
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quick one coming off semaglutide, is there a conversion or do i restart at 2.5
follow up is SURMOUNT-OSA the sleep apnoea one
at 2 my appetite went completely and i dropped back a step, eating nothing isnt a win, thats one data point
anyone got a 10 recon they like for the 10 vials
the GI difference held for me right up to 15, which isnt what a couple of people here found, ymmv
folklore probably
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)back after 13 months, do i restart at 2.5 or pick up near where i left off
the trials titrated every four weeks to a target, most people here stop at whatever works, i think
i argued the sweet spot was nonsense and then spent 6 months at 7.5 not needing more
is 7.5 really the sweet spot or is that just channel folklore
why does everyone talk about 7.5 and not 10
no gap when i switched, took the last semaglutide dose and started this a week later
changed my mind about needing 15, i was chasing a number rather than an outcome
did going from 0.5 semaglutide to 5 of this feel like a step down for anyone
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
did anyone find the GI easier than semaglutide at an equivalent effect
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
coming back to this i log everything and my appetite curve looks flatter across the week than my semaglutide log did
$94 for a 20 vial is roughly what ive paid for the last year
easier gi for me
the two compounds arent interchangeable week for week even if the effect ends up similar
i went to 15 and came back to 10, more suppression wasnt more useful for me, n of 1 obviously
im at 0.25 and thinking about 2.5, did anyone gain anything from that step
40 units of a 10 solution is a lot of volume and i check that one twice every single time
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
checked the units twice
7.5 gang
dual agonist, GIP as well as GLP-1, thats the whole difference in one line, i think
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how long before the dual thing was noticeable to you
how did people handle the 2.5 to 5 jump
genuine question switched last year
GIP plus GLP-1
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
[edited]start low anyway
no clean conversion
genuine question does switching from semaglutide need a gap or do you just start
the sweet spot thing is survivorship, the people it worked for stayed and said so, thats one data point