unrelated but at 0.5 my appetite went completely and i dropped back a step, eating nothing isnt a win
#tirzepatide 2025-09-27
Saturday34 messages8 participantstimes are UTC
Highlights from this day
- same_chromato — i sat at 7.5 for 12 months and never needed more, which is where the folklore comes from, ill dig out the number 22:52
- noct.titrate — GI was noticeably easier for me than semaglutide at what felt like the same appetite effect 23:36
- munich_mgml — held 10 for 25 months and lost 32kg over that stretch, slow and boring and fine 23:37
the trials titrated every four weeks to a target, most people here stop at whatever works
switched from 2.4 semaglutide and started at 2.5, took the slow route, never regretted it
slightly off topic but whats the top licensed dose, 15 or does it go higher
start low anyway
i sat at 7.5 for 12 months and never needed more, which is where the folklore comes from, ill dig out the number
changed my mind about needing 15, i was chasing a number rather than an outcome, thats one data point
10 was enough
there is no clean conversion between the two, anyone giving you a ratio is guessing
5 was where i first noticed it properly, 2.5 did almost nothing for me
restarted at 2.5 after 10 months off and the first two doses reminded me why titration exists
checked the units twice
slightly off topic but does the GIP arm actually explain the easier nausea or is that hand waving
how did people handle the 2.5 to 5 jump
the two compounds arent interchangeable week for week even if the effect ends up similar
5 did nothing
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
did anyone go past 15 and was there any point to it
genuine question SURMOUNT-1 versus SURPASS-2, which one was the weight trial
switched last year
15 is the top
coming off semaglutide, is there a conversion or do i restart at 2.5
easier gi for me
the GI difference held for me right up to 15, which isnt what a couple of people here found
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
at 7.5 my appetite is gone entirely, did anyone go down rather than up
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
[edited]❤️1🎉1
held 10 for 25 months and lost 32kg over that stretch, slow and boring and fine
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
SURMOUNT is weight
how long before the dual thing was noticeable to you
40 units of a 4 solution is a lot of volume and i check that one twice every single time
GIP plus GLP-1
is there a reason to titrate slower than the four week schedule
i log everything and my appetite curve looks flatter across the week than my semaglutide log did