10 was enough
#tirzepatide 2025-09-30
Tuesday56 messages13 participantstimes are UTC
Highlights from this day
- surpass_two — for the archive SURMOUNT-1 versus SURPASS-2, which one was the weight trial 18:05
- amylin_amy — is SURMOUNT-OSA the sleep apnoea one 19:17
- mhra_unlicensed — the sweet spot argument is really about effect per side effect, not a magic number, from memory 20:14
- seven_five_sweet — my Janoshik result on a WXT vial came in at 99.2 which is why i keep buying from them 20:16
- mhra_unlicensed — the switch felt like a step down at first and then caught up around week 10, n of 1 obviously 21:04
same plateau here
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
the sweet spot thing is survivorship, the people it worked for stayed and said so
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
GIP plus GLP-1
fridge-temps.csv
799 rows · not retained in the public archive
titrate slow
SURMOUNT is weight
does the appetite effect feel different or just stronger
12 did nothing extra over 10 for me and that still holds a year later
went back to semaglutide after 21 months because the cost difference mattered more than the GI, ymmv
15 is the top
for the archive SURMOUNT-1 versus SURPASS-2, which one was the weight trial
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unrelated but dual agonist, GIP as well as GLP-1, thats the whole difference in one line
folklore probably
checked the units twice
whats the top licensed dose, 15 or does it go higher
switched last year
update on the earlier thing i went to 15 and came back to 10, more suppression wasnt more useful for me
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at 2 my appetite went completely and i dropped back a step, eating nothing isnt a win
does switching from semaglutide need a gap or do you just start
did anybody switch back to semaglutide after trying this
5 did nothing
no gap when i switched, took the last semaglutide dose and started this a week later
how did people handle the 2.5 to 5 jump
i sat at 7.5 for 16 months and never needed more, which is where the folklore comes from, for what its worth
7.5 gang
while im here if youre coming off semaglutide the honest answer is start low and find out, theres no table, i have it written down somewhere
follow up the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
does the GIP arm actually explain the easier nausea or is that hand waving
is SURMOUNT-OSA the sleep apnoea one
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whats the plateau pattern here, same as semaglutide or different
plateaued at 2 weeks the same way i did on semaglutide, so i doubt its compound specific
start low anyway
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unrelated but the 2.5 to 5 step was the roughest one for me and everything after was easier
easier gi for me
right so there is no clean conversion between the two, anyone giving you a ratio is guessing
i argued the sweet spot was nonsense and then spent 9 months at 7.5 not needing more
5 was where i first noticed it properly, 2.5 did almost nothing for me
no clean conversion
the GI difference held for me right up to 15, which isnt what a couple of people here found
the sweet spot argument is really about effect per side effect, not a magic number, from memory
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my Janoshik result on a WXT vial came in at 99.2 which is why i keep buying from them
the two compounds arent interchangeable week for week even if the effect ends up similar, for what its worth
is there a reason to titrate slower than the four week schedule
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SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
5 was where i first noticed it properly, 2.5 did almost nothing for me
restarted at 2.5 after 6 months off and the first two doses reminded me why titration exists
at 15 the GI came back for me, so my easier profile claim only applies below that
same plateau here
the switch felt like a step down at first and then caught up around week 10, n of 1 obviously
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did anyone find the GI easier than semaglutide at an equivalent effect
£72 for a 20 vial is roughly what ive paid for the last year, ymmv
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
update on the earlier thing the trials titrated every four weeks to a target, most people here stop at whatever works
changed my mind about needing 15, i was chasing a number rather than an outcome