folklore probably
#tirzepatide 2025-10-23
Thursday22 messages5 participantstimes are UTC
Highlights from this day
- is_this_forever — while im here did going from 1.7 semaglutide to 5 of this feel like a step down for anyone 19:23
- glucagon_arm — i sat at 7.5 for 18 months and never needed more, which is where the folklore comes from 19:40
- deamidation — 40 units of a 8 solution is a lot of volume and i check that one twice every single time 20:12
- deamidation — at 7.5 my appetite is gone entirely, did anyone go down rather than up 20:44
- deamidation — sorry to jump in did anybody switch back to semaglutide after trying this the sweet spot thing is survivorship, the people it worked for stayed and said so 21:07
did anyone go past 15 and was there any point to it
anyone got a 5 recon they like for the 30 vials
the 40 vial in 2.5ml gives 2mg/ml which puts 1.7 on 12 units, nice round numbers, take that with a pinch of salt
7.5 gang
while im here did going from 1.7 semaglutide to 5 of this feel like a step down for anyone
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)i sat at 7.5 for 18 months and never needed more, which is where the folklore comes from
🙏18📉14
the sweet spot argument is really about effect per side effect, not a magic number, i could be wrong
is 7.5 really the sweet spot or is that just channel folklore
plateaued at 25 weeks the same way i did on semaglutide, so i doubt its compound specific
i argued the sweet spot was nonsense and then spent 21 months at 7.5 not needing more
✅1
switched from 2 semaglutide and started at 2.5, took the slow route, never regretted it
no clean conversion
40 units of a 8 solution is a lot of volume and i check that one twice every single time
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
titrate slow
easier gi for me
🎉2🔥17📈12
back after 4 months, do i restart at 2.5 or pick up near where i left off
10 was enough
🔥7👀5
at 7.5 my appetite is gone entirely, did anyone go down rather than up
❤️10📉6⚠️13
same plateau here
changed my mind about needing 15, i was chasing a number rather than an outcome, i think
sorry to jump in did anybody switch back to semaglutide after trying this
the sweet spot thing is survivorship, the people it worked for stayed and said so