i sat at 7.5 for 8 months and never needed more, which is where the folklore comes from
#tirzepatide 2025-10-24
Friday48 messages10 participantstimes are UTC
Highlights from this day
- gip_glp_gil — is the 20 vial the common one or do people use 15 09:43
- snac_and_water — slightly off topic but the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact 10:20
- first_and_last_four — slightly off topic but my VendorInvestigate result on a BCH vial came in at 99.4 which is why i keep buying from them 10:25
- tga_notice — the 20 vial in 1.5ml gives 8mg/ml which puts 15 on 50 units, nice round numbers 12:32
- tga_notice — SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted, from memory 15:27
is the 20 vial the common one or do people use 15
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start low anyway
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
while im here did anybody switch back to semaglutide after trying this
7.5 gang
easier gi for me
checked the units twice
slightly off topic but the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
went back to semaglutide after 24 months because the cost difference mattered more than the GI
is there a reason to titrate slower than the four week schedule
slightly off topic but my VendorInvestigate result on a BCH vial came in at 99.4 which is why i keep buying from them
10 was enough
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whats the plateau pattern here, same as semaglutide or different
coming off semaglutide, is there a conversion or do i restart at 2.5
did going from 12 semaglutide to 5 of this feel like a step down for anyone
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect, n of 1 obviously
15 is the top
slightly off topic but at 2 my appetite went completely and i dropped back a step, eating nothing isnt a win
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
is the sweet spot argument about effect or about side effects
i went to 15 and came back to 10, more suppression wasnt more useful for me
restarted at 2.5 after 6 months off and the first two doses reminded me why titration exists
whats the top licensed dose, 15 or does it go higher
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
ok so at 15 the GI came back for me, so my easier profile claim only applies below that
did anyone find the GI easier than semaglutide at an equivalent effect
how many weeks at 7.5 before you knew it was enough
the 20 vial in 1.5ml gives 8mg/ml which puts 15 on 50 units, nice round numbers
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the two compounds arent interchangeable week for week even if the effect ends up similar
does the appetite effect feel different or just stronger
the GI difference held for me right up to 15, which isnt what a couple of people here found, anyway
unrelated but if youre coming off semaglutide the honest answer is start low and find out, theres no table
anyone got a 4 recon they like for the 15 vials
GIP plus GLP-1
switched last year
does the GIP arm actually explain the easier nausea or is that hand waving
5 did nothing
no gap when i switched, took the last semaglutide dose and started this a week later
there is no clean conversion between the two, anyone giving you a ratio is guessing
SURMOUNT is weight
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same plateau here
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back after 11 months, do i restart at 2.5 or pick up near where i left off
the 2.5 to 5 step was the roughest one for me and everything after was easier
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted, from memory
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titrate slow
i argued the sweet spot was nonsense and then spent 6 months at 7.5 not needing more
did anyone go past 15 and was there any point to it