vialroom

#tirzepatide 2025-10-27

Monday27 messages6 participantstimes are UTC
Highlights from this day
  • dez_domains — i log everything and my appetite curve looks flatter across the week than my semaglutide log did 20:05
  • dez_domains — the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact, anyway 20:16
  • dez_domains — whats the plateau pattern here, same as semaglutide or different 20:43
  • fibre_first — held 10 for 24 months and lost 46kg over that stretch, slow and boring and fine 21:33
DD

my PeptideMeter result on a KP vial came in at 98.1 which is why i keep buying from them

i log everything and my appetite curve looks flatter across the week than my semaglutide log did

🧊13🤝12
ST

the trials titrated every four weeks to a target, most people here stop at whatever works

DD

the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact, anyway

📈18🤝5🧪1
DD

there is no clean conversion between the two, anyone giving you a ratio is guessing, your mileage will differ

DD

whats the plateau pattern here, same as semaglutide or different

🧪5⚠️9📉2
DD

the switch felt like a step down at first and then caught up around week 7, not advice obviously

the 15 vial in 5ml gives 2mg/ml which puts 7.5 on 10 units, nice round numbers

VB

Inter-lab diff for lot H-2814: 98.1% vs 99.4%. Within expected range.

DD

12 did nothing extra over 10 for me and that still holds a year later, happy to be corrected

😂5

checked the units twice

🙏8🎉18

€185 for a 20 vial is roughly what ive paid for the last year

the GI difference held for me right up to 15, which isnt what a couple of people here found

FF

at 0.5 my appetite is gone entirely, did anyone go down rather than up

Trial scheduleWhat most people here do
Step interval4 weeks, fixed4-12 weeks, on symptoms
Holdingprotocol deviationnormal and expected
Top dosereached by designoften never reached
Coming downnot studiedcommon at maintenance

5 was where i first noticed it properly, 2.5 did almost nothing for me

how long before the dual thing was noticeable to you

VB

Inter-lab diff for lot B-0329: 99.2% vs 99.4%. Within expected range.

⚠️1
FF

unrelated but GI was noticeably easier for me than semaglutide at what felt like the same appetite effect

dual agonist, GIP as well as GLP-1, thats the whole difference in one line

PP

ok so how did people handle the 2.5 to 5 jump

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FF

held 10 for 24 months and lost 46kg over that stretch, slow and boring and fine

🤝1🎉18

SURMOUNT is weight

ST

ok so coming off semaglutide, is there a conversion or do i restart at 2.5

i sat at 7.5 for 23 months and never needed more, which is where the folklore comes from

easier gi for me