SURMOUNT is weight
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#tirzepatide 2025-11-02
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update on the earlier thing SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
is the 30 vial the common one or do people use 15
im at 2.5 and thinking about 5, did anyone gain anything from that step
start low anyway
the trials titrated every four weeks to a target, most people here stop at whatever works
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
*PeptideMeter not the other one
anyone got a 10 recon they like for the 15 vials
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does, your mileage will differ
On this day 9 years ago this channel logged 105 messages.
the two compounds arent interchangeable week for week even if the effect ends up similar
did going from 0.5 semaglutide to 5 of this feel like a step down for anyone
quick one the GI difference held for me right up to 15, which isnt what a couple of people here found
[edited]switched last year
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quick one at 5 my appetite is gone entirely, did anyone go down rather than up
easier gi for me
i went to 15 and came back to 10, more suppression wasnt more useful for me
anyone tracked whether the GI difference held at the top doses
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the sweet spot thing is survivorship, the people it worked for stayed and said so, i think
back after 9 months, do i restart at 2.5 or pick up near where i left off
GIP plus GLP-1
does switching from semaglutide need a gap or do you just start
no gap when i switched, took the last semaglutide dose and started this a week later
*week 13 not week 7
the 2 vial in 1ml gives 4mg/ml which puts 12 on 50 units, nice round numbers, thats just me
restarted at 2.5 after 17 months off and the first two doses reminded me why titration exists
my Medutest result on a BCH vial came in at 99.2 which is why i keep buying from them
does the GIP arm actually explain the easier nausea or is that hand waving
the switch felt like a step down at first and then caught up around week 5
there is no clean conversion between the two, anyone giving you a ratio is guessing
is SURMOUNT-OSA the sleep apnoea one
whats the top licensed dose, 15 or does it go higher
💀12🎉15📈10
*Medutest not the other one
at 2.4 my appetite went completely and i dropped back a step, eating nothing isnt a win
is 7.5 really the sweet spot or is that just channel folklore
5 did nothing
5 was where i first noticed it properly, 2.5 did almost nothing for me
checked the units twice
changed my mind about needing 15, i was chasing a number rather than an outcome, anyway
*Janoshik not the other one
folklore probably
at 15 the GI came back for me, so my easier profile claim only applies below that
how long before the dual thing was noticeable to you
held 10 for 18 months and lost 38kg over that stretch, slow and boring and fine
right so how many weeks at 7.5 before you knew it was enough
10 was enough
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the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
while im here 40 units of a 4 solution is a lot of volume and i check that one twice every single time
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect, ill dig out the number
for the archive SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
12 did nothing extra over 10 for me and that still holds a year later
7.5 gang
peptidemeter-summary-kp-0925.pdf
2 pages · 524 KB · not retained in the public archive
is the sweet spot argument about effect or about side effects
same plateau here
does the appetite effect feel different or just stronger
why does everyone talk about 7.5 and not 10
switched from 15 semaglutide and started at 2.5, took the slow route, never regretted it
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titrate slow
$38 for a 30 vial is roughly what ive paid for the last year, thats just me
dual agonist, GIP as well as GLP-1, thats the whole difference in one line, ask me again in a month
*Janoshik not the other one
update on the earlier thing same plateau here
ok so if youre coming off semaglutide the honest answer is start low and find out, theres no table
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no clean conversion
easier gi for me
40 units of a 5 solution is a lot of volume and i check that one twice every single time