7.5 gang
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
#tirzepatide 2025-11-11
Tuesday14 messages6 participantstimes are UTC
Highlights from this day
- ruo_only — SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up 20:45
- ruo_only — went back to semaglutide after 8 months because the cost difference mattered more than the GI 20:48
- ruo_only — does the appetite effect feel different or just stronger 20:49
- private_script_pri — restarted at 2.5 after 14 months off and the first two doses reminded me why titration exists 21:49
- auckland_aliquot — switched from 1.7 semaglutide and started at 2.5, took the slow route, never regretted it 23:16
anyone tracked whether the GI difference held at the top doses
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
😂1
went back to semaglutide after 8 months because the cost difference mattered more than the GI
does the appetite effect feel different or just stronger
⚠️17
at 1.7 my appetite is gone entirely, did anyone go down rather than up
at 15 the GI came back for me, so my easier profile claim only applies below that
the two compounds arent interchangeable week for week even if the effect ends up similar
the 2.5 to 5 step was the roughest one for me and everything after was easier
10 was enough
👍9
restarted at 2.5 after 14 months off and the first two doses reminded me why titration exists
[edited]genuine question is the sweet spot argument about effect or about side effects
switched from 1.7 semaglutide and started at 2.5, took the slow route, never regretted it