vialroom

#tirzepatide 2025-11-14

Friday37 messages9 participantstimes are UTC
Highlights from this day
  • vale_vials — why does everyone talk about 7.5 and not 10 02:56
  • VialBot — Digest for the week of 2025-05-08 has been published. 03:07
  • gip_glp_gil — the sweet spot thing is survivorship, the people it worked for stayed and said so 07:15
  • food_noise_off — sorry to jump in is the sweet spot argument about effect or about side effects 08:17
  • gip_glp_gil — does the appetite effect feel different or just stronger 08:28
VV

restarted at 2.5 after 19 months off and the first two doses reminded me why titration exists, not advice obviously

why does everyone talk about 7.5 and not 10

🧪17💀10
HH

while im here held 10 for 13 months and lost 29kg over that stretch, slow and boring and fine

at 5 my appetite is gone entirely, did anyone go down rather than up

VV

the GI difference held for me right up to 15, which isnt what a couple of people here found

VB

Digest for the week of 2025-05-08 has been published.

VV

SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted

[edited]
HH

ok so im at 15 and thinking about 2.4, did anyone gain anything from that step

HH

genuine question did anyone find the GI easier than semaglutide at an equivalent effect

MP

is 7.5 really the sweet spot or is that just channel folklore

MP

the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact

GG

sorry to jump in 40 units of a 8 solution is a lot of volume and i check that one twice every single time

MP

went back to semaglutide after 19 months because the cost difference mattered more than the GI

switched last year

GG

SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up

start low anyway

HH

the sweet spot argument is really about effect per side effect, not a magic number, thats one data point

GG

the sweet spot thing is survivorship, the people it worked for stayed and said so

Cited study
Tirzepatide versus Semaglutide Once Weekly in Type 2 Diabetes (SURPASS-2)
New England Journal of Medicine · 2021
The head-to-head everyone quotes. Note the semaglutide comparator dose.
GG

sorry to jump in at 15 the GI came back for me, so my easier profile claim only applies below that

HH

genuine question back after 15 months, do i restart at 2.5 or pick up near where i left off

HH

coming back to this $38 for a 2 vial is roughly what ive paid for the last year

📉4
FN

sorry to jump in is the sweet spot argument about effect or about side effects

❤️12

SURMOUNT-1 versus SURPASS-2, which one was the weight trial
restarted at 2.5 after 26 months off and the first two doses reminded me why titration exists

titrate slow

FN

the 5 vial in 0.5ml gives 10mg/ml which puts 12 on 5 units, nice round numbers

same plateau here

🧊10
GG

does the appetite effect feel different or just stronger

🧊11🎉6❤️17