unrelated but switched from 1.7 semaglutide and started at 2.5, took the slow route, never regretted it
#tirzepatide 2026-01-07
Wednesday61 messages12 participantstimes are UTC
Highlights from this day
- ghent_gradient — the two compounds arent interchangeable week for week even if the effect ends up similar the 2.5 to 5 step was the roughest one for me and everything after was easier 16:59
- LC_MS_Lena — went back to semaglutide after 8 months because the cost difference mattered more than the GI 17:18
- ring_size_down — the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact 17:56
does the GIP arm actually explain the easier nausea or is that hand waving
[edited]titrate slow
start low anyway
switched last year
whats the top licensed dose, 15 or does it go higher
im at 15 and thinking about 1, did anyone gain anything from that step
Archive lookup: thirty_min_wait first appears in this channel on 2025-03-04.
same plateau here
at 5 my appetite is gone entirely, did anyone go down rather than up
at 2 my appetite went completely and i dropped back a step, eating nothing isnt a win
follow up coming off semaglutide, is there a conversion or do i restart at 2.5
switched from 12 semaglutide and started at 2.5, took the slow route, never regretted it
how many weeks at 7.5 before you knew it was enough
15 is the top
no gap when i switched, took the last semaglutide dose and started this a week later
🎉2
SURMOUNT is weight
👍4🎉5
restarted at 2.5 after 3 months off and the first two doses reminded me why titration exists
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update on the earlier thing is the 15 vial the common one or do people use 5
anyone got a 2.5 recon they like for the 40 vials
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
i argued the sweet spot was nonsense and then spent 22 months at 7.5 not needing more
the 30 vial in 0.5ml gives 4mg/ml which puts 1.7 on 25 units, nice round numbers, thats just me
the trials titrated every four weeks to a target, most people here stop at whatever works, someone check my working
changed my mind about needing 15, i was chasing a number rather than an outcome
i went to 15 and came back to 10, more suppression wasnt more useful for me
right so the sweet spot thing is survivorship, the people it worked for stayed and said so
5 did nothing
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)easier gi for me
checked the units twice
🤝14❤️9
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
no clean conversion
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
folklore probably
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
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GIP plus GLP-1
lot-log.csv
408 rows · not retained in the public archive
the switch felt like a step down at first and then caught up around week 14
10 was enough
7.5 gang
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40 units of a 10 solution is a lot of volume and i check that one twice every single time
the two compounds arent interchangeable week for week even if the effect ends up similar
the 2.5 to 5 step was the roughest one for me and everything after was easier
🙏15🧊8📉8
went back to semaglutide after 8 months because the cost difference mattered more than the GI
❤️18🧪6👍18
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
weights-monthly.csv
354 rows · not retained in the public archive
my PeptideMeter result on a QSC vial came in at 99 which is why i keep buying from them
the sweet spot argument is really about effect per side effect, not a magic number
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anyone stopped at 10 and stayed there for months
right so did anybody switch back to semaglutide after trying this
the 2.5 to 5 step was the roughest one for me and everything after was easier
coming back to this how long before the dual thing was noticeable to you
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
🤝7❤️15
the GI difference held for me right up to 15, which isnt what a couple of people here found
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
📉15
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
i argued the sweet spot was nonsense and then spent 21 months at 7.5 not needing more, ask me again in a month
at 15 the GI came back for me, so my easier profile claim only applies below that
quick one 5 did nothing
plateaued at 5 weeks the same way i did on semaglutide, so i doubt its compound specific
back after 25 months, do i restart at 2.5 or pick up near where i left off
[edited]| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
i sat at 7.5 for 10 months and never needed more, which is where the folklore comes from
SURMOUNT is weight
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i argued the sweet spot was nonsense and then spent 8 months at 7.5 not needing more
12 did nothing extra over 10 for me and that still holds a year later
5 was where i first noticed it properly, 2.5 did almost nothing for me