switched from 7.5 semaglutide and started at 2.5, took the slow route, never regretted it, ymmv
#tirzepatide 2026-01-22
Thursday40 messages9 participantstimes are UTC
Highlights from this day
- rotterdam_recon — changed my mind about needing 15, i was chasing a number rather than an outcome, for what its worth 17:04
- alcohol_hits — restarted at 2.5 after 26 months off and the first two doses reminded me why titration exists, i think 17:11
- monoisotopic — the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact, ill dig out the number 17:53
- noct.titrate — dual agonist, GIP as well as GLP-1, thats the whole difference in one line i went to 15 and came back to 10, more suppression wasnt more useful for me 18:15
whats the top licensed dose, 15 or does it go higher
the switch felt like a step down at first and then caught up around week 13
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did going from 5 semaglutide to 5 of this feel like a step down for anyone
[edited]€72 for a 15 vial is roughly what ive paid for the last year
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
changed my mind about needing 15, i was chasing a number rather than an outcome, for what its worth
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folklore probably
SURMOUNT is weight
no clean conversion
restarted at 2.5 after 26 months off and the first two doses reminded me why titration exists, i think
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i argued the sweet spot was nonsense and then spent 14 months at 7.5 not needing more, i have it written down somewhere
*VendorInvestigate not the other one
anyone stopped at 10 and stayed there for months
15 is the top
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sorry to jump in is the sweet spot argument about effect or about side effects
the sweet spot thing is survivorship, the people it worked for stayed and said so
my VendorInvestigate result on a SGN vial came in at 99.2 which is why i keep buying from them
same plateau here
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
coming off semaglutide, is there a conversion or do i restart at 2.5
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact, ill dig out the number
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Purity check: no report on file for lot SG-1177. Nothing logged either way.
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start low anyway
there is no clean conversion between the two, anyone giving you a ratio is guessing, ill dig out the number
checked the units twice
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10 was enough
how did people handle the 2.5 to 5 jump
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
i went to 15 and came back to 10, more suppression wasnt more useful for me
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does the appetite effect feel different or just stronger
easier gi for me
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how many weeks at 7.5 before you knew it was enough
follow up 12 did nothing extra over 10 for me and that still holds a year later, i have it written down somewhere
the GI difference held for me right up to 15, which isnt what a couple of people here found
5 was where i first noticed it properly, 2.5 did almost nothing for me, we shall see
is there a reason to titrate slower than the four week schedule
7.5 gang
sorry to jump in SURMOUNT-1 versus SURPASS-2, which one was the weight trial
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switched last year
plateaued at 5 weeks the same way i did on semaglutide, so i doubt its compound specific
the trials titrated every four weeks to a target, most people here stop at whatever works