is 7.5 really the sweet spot or is that just channel folklore
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#tirzepatide 2026-01-24
Saturday71 messages14 participantstimes are UTC
Highlights from this day
- lisbon_lot — the sweet spot argument is really about effect per side effect, not a magic number 11:01
- spreadsheet_stu — licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does 13:14
- thank_you_year_on — switched last year, still working it out 14:34
- quill_questions — SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted 18:06
did anyone go past 15 and was there any point to it
my Janoshik result on a FGP vial came in at 99.2 which is why i keep buying from them
40 units of a 2 solution is a lot of volume and i check that one twice every single time
anyone tracked whether the GI difference held at the top doses
held 10 for 24 months and lost 12kg over that stretch, slow and boring and fine
€55 for a 10 vial is roughly what ive paid for the last year
10 was enough
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i log everything and my appetite curve looks flatter across the week than my semaglutide log did
there is no clean conversion between the two, anyone giving you a ratio is guessing
slightly off topic but anyone got a 2.5 recon they like for the 15 vials
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
i argued the sweet spot was nonsense and then spent 7 months at 7.5 not needing more
plateaued at 8 weeks the same way i did on semaglutide, so i doubt its compound specific
the two compounds arent interchangeable week for week even if the effect ends up similar
the switch felt like a step down at first and then caught up around week 32
how did people handle the 2.5 to 5 jump
start low anyway
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the sweet spot argument is really about effect per side effect, not a magic number
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)the 30 vial in 5ml gives 5mg/ml which puts 12 on 15 units, nice round numbers, anyway
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SURMOUNT is weight
coming back to this 12 did nothing extra over 10 for me and that still holds a year later
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
quick one SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
ok so the sweet spot thing is survivorship, the people it worked for stayed and said so
at 2.5 my appetite went completely and i dropped back a step, eating nothing isnt a win
no gap when i switched, took the last semaglutide dose and started this a week later
does the GIP arm actually explain the easier nausea or is that hand waving
5 was where i first noticed it properly, 2.5 did almost nothing for me
is the sweet spot argument about effect or about side effects
the GI difference held for me right up to 15, which isnt what a couple of people here found, thats one data point
easier gi for me
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the trials titrated every four weeks to a target, most people here stop at whatever works
if youre coming off semaglutide the honest answer is start low and find out, theres no table
why does everyone talk about 7.5 and not 10
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
changed my mind about needing 15, i was chasing a number rather than an outcome, thats just me
at 15 the GI came back for me, so my easier profile claim only applies below that, i think
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
ok so dual agonist, GIP as well as GLP-1, thats the whole difference in one line
5 did nothing
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
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no clean conversion
Reminder for thank_you_year_on: dose day is today. Set 5 days ago.
i went to 15 and came back to 10, more suppression wasnt more useful for me
restarted at 2.5 after 4 months off and the first two doses reminded me why titration exists
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follow up same plateau here
went back to semaglutide after 20 months because the cost difference mattered more than the GI
folklore probably
switched from 2 semaglutide and started at 2.5, took the slow route, never regretted it
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titrate slow
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switched last year, still working it out
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
7.5 gang
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10 was enough
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5 did nothing, i could be wrong
quill_questionsif youre coming off semaglutide the honest answer is start low and find out, theres no…
the 2.5 to 5 step was the roughest one for me and everything after was easier
folklore probably, not advice obviously
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
did anybody switch back to semaglutide after trying this
how long before the dual thing was noticeable to you
is SURMOUNT-OSA the sleep apnoea one
checked the units twice
GIP plus GLP-1
ok so i sat at 7.5 for 14 months and never needed more, which is where the folklore comes from
the two compounds arent interchangeable week for week even if the effect ends up similar
start low anyway
update on the earlier thing 5 did nothing
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coming off semaglutide, is there a conversion or do i restart at 2.5
15 is the top
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no clean conversion
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
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switched last year, your mileage will differ