how did people handle the 2.5 to 5 jump
[edited]#tirzepatide 2026-01-28
Wednesday28 messages6 participantstimes are UTC
Highlights from this day
- eight_mm — 40 units of a 2.5 solution is a lot of volume and i check that one twice every single time 13:56
- nhs_pathway_nell — no gap when i switched, took the last semaglutide dose and started this a week later 14:40
- ring_size_down — the switch felt like a step down at first and then caught up around week 14 at 15 the GI came back for me, so my easier profile claim only applies below that 15:22
- stable_not_volatile — update on the earlier thing i went to 15 and came back to 10, more suppression wasnt more useful for me, someone check my working 16:13
15 is the top
the trials titrated every four weeks to a target, most people here stop at whatever works
40 units of a 2.5 solution is a lot of volume and i check that one twice every single time
5 was where i first noticed it properly, 2.5 did almost nothing for me
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
SURMOUNT is weight
same plateau here
while im here is 7.5 really the sweet spot or is that just channel folklore
no gap when i switched, took the last semaglutide dose and started this a week later
lot-log.csv
728 rows · not retained in the public archive
start low anyway
folklore probably
i sat at 7.5 for 20 months and never needed more, which is where the folklore comes from
the switch felt like a step down at first and then caught up around week 14
at 15 the GI came back for me, so my easier profile claim only applies below that
titrate slow
quick one whats the top licensed dose, 15 or does it go higher
is the 5 vial the common one or do people use 30
coming off semaglutide, is there a conversion or do i restart at 2.5
there is no clean conversion between the two, anyone giving you a ratio is guessing
12 did nothing extra over 10 for me and that still holds a year later
update on the earlier thing i went to 15 and came back to 10, more suppression wasnt more useful for me, someone check my working
🤝5💀17👍1
no clean conversion
👍10
plateaued at 17 weeks the same way i did on semaglutide, so i doubt its compound specific
7.5 gang
$72 for a 10 vial is roughly what ive paid for the last year
checked the units twice
💀15🤝5👀1
does the appetite effect feel different or just stronger
i argued the sweet spot was nonsense and then spent 18 months at 7.5 not needing more