10 was enough
#tirzepatide 2026-02-14
Saturday38 messages9 participantstimes are UTC
Highlights from this day
- otto_swirls — i log everything and my appetite curve looks flatter across the week than my semaglutide log did 12:42
- amber_vial — ok so is the sweet spot argument about effect or about side effects 15:57
- amber_vial — ok so licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does 16:05
- amber_vial — follow up the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact at 2.4 my appetite went completely and i dropped back a step,… 16:15
genuine question SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted, thats one data point
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
📈13❤️15
start low anyway
i sat at 7.5 for 15 months and never needed more, which is where the folklore comes from
15 is the top
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)🎉9👀2
easier gi for me
[edited]📉1
titrate slow
how long before the dual thing was noticeable to you
❤️1
if youre coming off semaglutide the honest answer is start low and find out, theres no table
👍3
plateaued at 31 weeks the same way i did on semaglutide, so i doubt its compound specific
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
did anyone go past 15 and was there any point to it
the 10 vial in 1ml gives 5mg/ml which puts 0.5 on 8 units, nice round numbers, for what its worth
the trials titrated every four weeks to a target, most people here stop at whatever works
how did people handle the 2.5 to 5 jump
🧪2
whats the top licensed dose, 15 or does it go higher
at 0.5 my appetite went completely and i dropped back a step, eating nothing isnt a win
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
the switch felt like a step down at first and then caught up around week 18
no clean conversion
peptidemeter-summary-b-0114.pdf
2 pages · 433 KB · not retained in the public archive
🤝7
SURMOUNT is weight
40 units of a 2 solution is a lot of volume and i check that one twice every single time, from memory
sorry to jump in coming off semaglutide, is there a conversion or do i restart at 2.5
£38 for a 30 vial is roughly what ive paid for the last year
no gap when i switched, took the last semaglutide dose and started this a week later
im at 0.25 and thinking about 2, did anyone gain anything from that step
sorry to jump in there is no clean conversion between the two, anyone giving you a ratio is guessing
i argued the sweet spot was nonsense and then spent 18 months at 7.5 not needing more
did anyone find the GI easier than semaglutide at an equivalent effect
same plateau here
ok so is the sweet spot argument about effect or about side effects
🎉7🙏1
7.5 gang
is there a reason to titrate slower than the four week schedule
👀4🔥2
ok so licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
😂11👀1🔥7
follow up the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
at 2.4 my appetite went completely and i dropped back a step, eating nothing isnt a win
⚠️3🎉11👀2
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
5 did nothing
why does everyone talk about 7.5 and not 10