whats the top licensed dose, 15 or does it go higher
#tirzepatide 2026-02-15
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whats the plateau pattern here, same as semaglutide or different
7.5 gang
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i sat at 7.5 for 6 months and never needed more, which is where the folklore comes from
the 5 vial in 2.5ml gives 2mg/ml which puts 15 on 15 units, nice round numbers
did going from 2.5 semaglutide to 5 of this feel like a step down for anyone
did anybody switch back to semaglutide after trying this
10 was enough
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
i went to 15 and came back to 10, more suppression wasnt more useful for me
if youre coming off semaglutide the honest answer is start low and find out, theres no table
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how many weeks at 7.5 before you knew it was enough
how did people handle the 2.5 to 5 jump
40 units of a 5 solution is a lot of volume and i check that one twice every single time
[edited]wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)did anyone find the GI easier than semaglutide at an equivalent effect
restarted at 2.5 after 23 months off and the first two doses reminded me why titration exists
15 is the top
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
the trials titrated every four weeks to a target, most people here stop at whatever works, thats one data point
at 2.5 my appetite went completely and i dropped back a step, eating nothing isnt a win
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plateaued at 5 weeks the same way i did on semaglutide, so i doubt its compound specific, from memory
update on the earlier thing at 15 the GI came back for me, so my easier profile claim only applies below that
the 2.5 to 5 step was the roughest one for me and everything after was easier
held 10 for 17 months and lost 5kg over that stretch, slow and boring and fine, ymmv
folklore probably
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SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
sorry to jump in €120 for a 20 vial is roughly what ive paid for the last year
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dual agonist, GIP as well as GLP-1, thats the whole difference in one line
how long before the dual thing was noticeable to you
SURMOUNT is weight
5 was where i first noticed it properly, 2.5 did almost nothing for me, we shall see
my Janoshik result on a MKM vial came in at 98.6 which is why i keep buying from them
is there a reason to titrate slower than the four week schedule
update on the earlier thing anyone stopped at 10 and stayed there for months
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
switched last year
does switching from semaglutide need a gap or do you just start
the 2.5 to 5 step was the roughest one for me and everything after was easier
*Medutest not the other one
the GI difference held for me right up to 15, which isnt what a couple of people here found
does the GIP arm actually explain the easier nausea or is that hand waving
is SURMOUNT-OSA the sleep apnoea one
anyone tracked whether the GI difference held at the top doses
same plateau here
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went back to semaglutide after 1 months because the cost difference mattered more than the GI
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
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anyone got a 2 recon they like for the 40 vials
im at 0.5 and thinking about 7.5, did anyone gain anything from that step
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changed my mind about needing 15, i was chasing a number rather than an outcome
back after 4 months, do i restart at 2.5 or pick up near where i left off
Recon calculator: 40mg in 2.5ml = 2mg/ml.
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the sweet spot argument is really about effect per side effect, not a magic number
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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assay_not_puritythe GIP explanation for easier nausea is plausible and i still treat it as a story not…
the two compounds arent interchangeable week for week even if the effect ends up similar
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12 did nothing extra over 10 for me and that still holds a year later
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5 did nothing
the 2.5 to 5 step was the roughest one for me and everything after was easier
no gap when i switched, took the last semaglutide dose and started this a week later
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coming off semaglutide, is there a conversion or do i restart at 2.5
[edited]checked the units twice, your mileage will differ
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is the sweet spot argument about effect or about side effects
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the sweet spot thing is survivorship, the people it worked for stayed and said so
for the archive no clean conversion
slightly off topic but switched from 15 semaglutide and started at 2.5, took the slow route, never regretted it
i argued the sweet spot was nonsense and then spent 10 months at 7.5 not needing more
10 was enough, thats just me
[edited]is the 40 vial the common one or do people use 30
titrate slow
Verification log updated: ERP — evidence added, status unchanged.
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licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
the switch felt like a step down at first and then caught up around week 18
i went to 15 and came back to 10, more suppression wasnt more useful for me
titrate slow, take that with a pinch of salt
why does everyone talk about 7.5 and not 10
[edited]same plateau here
there is no clean conversion between the two, anyone giving you a ratio is guessing
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)