how did people handle the 2.5 to 5 jump
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#tirzepatide 2026-02-22
Sunday25 messages5 participantstimes are UTC
Highlights from this day
- adelaide_assay — how did people handle the 2.5 to 5 jump 21:04
- adelaide_assay — did anyone go past 15 and was there any point to it 21:18
- snac_and_water — is there a reason to titrate slower than the four week schedule 21:33
- amylin_amy — restarted at 2.5 after 17 months off and the first two doses reminded me why titration exists, ill dig out the number 22:03
- nausea_window — the GI difference held for me right up to 15, which isnt what a couple of people here found, anyway 22:37
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
did anyone go past 15 and was there any point to it
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is SURMOUNT-OSA the sleep apnoea one
ok so anyone stopped at 10 and stayed there for months
7.5 gang
is there a reason to titrate slower than the four week schedule
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the sweet spot thing is survivorship, the people it worked for stayed and said so
im at 2 and thinking about 12, did anyone gain anything from that step
titrate slow
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no clean conversion
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start low anyway
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
GIP plus GLP-1
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
there is no clean conversion between the two, anyone giving you a ratio is guessing
no gap when i switched, took the last semaglutide dose and started this a week later
restarted at 2.5 after 17 months off and the first two doses reminded me why titration exists, ill dig out the number
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if youre coming off semaglutide the honest answer is start low and find out, theres no table
plateaued at 13 weeks the same way i did on semaglutide, so i doubt its compound specific
*VendorInvestigate not the other one
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
the GI difference held for me right up to 15, which isnt what a couple of people here found, anyway
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did anyone find the GI easier than semaglutide at an equivalent effect
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40 units of a 5 solution is a lot of volume and i check that one twice every single time
at 5 my appetite went completely and i dropped back a step, eating nothing isnt a win