slightly off topic but GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
#tirzepatide 2026-02-23
Monday49 messages11 participantstimes are UTC
Highlights from this day
is the sweet spot argument about effect or about side effects
at 15 the GI came back for me, so my easier profile claim only applies below that
10 was enough
is the 15 vial the common one or do people use 5
checked the units twice
the trials titrated every four weeks to a target, most people here stop at whatever works
peptidemeter-summary-e-2205.pdf
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coming off semaglutide, is there a conversion or do i restart at 2.5
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SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
anyone got a 2 recon they like for the 30 vials
did anyone find the GI easier than semaglutide at an equivalent effect
there is no clean conversion between the two, anyone giving you a ratio is guessing, i think
how long before the dual thing was noticeable to you
folklore probably
i sat at 7.5 for 5 months and never needed more, which is where the folklore comes from
whats the top licensed dose, 15 or does it go higher
easier gi for me
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
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15 is the top
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does switching from semaglutide need a gap or do you just start
anyone tracked whether the GI difference held at the top doses
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40 units of a 2.5 solution is a lot of volume and i check that one twice every single time
is SURMOUNT-OSA the sleep apnoea one
does the appetite effect feel different or just stronger
titrate slow
genuine question held 10 for 11 months and lost 38kg over that stretch, slow and boring and fine
*that should say weekly
slightly off topic but the 40 vial in 1.5ml gives 2.5mg/ml which puts 7.5 on 8 units, nice round numbers
12 did nothing extra over 10 for me and that still holds a year later
SURMOUNT is weight
7.5 gang
im at 0.25 and thinking about 0.5, did anyone gain anything from that step
at 12 my appetite went completely and i dropped back a step, eating nothing isnt a win
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back after 6 months, do i restart at 2.5 or pick up near where i left off
same plateau here
5 was where i first noticed it properly, 2.5 did almost nothing for me
switched last year
GIP plus GLP-1
did anyone go past 15 and was there any point to it
went back to semaglutide after 20 months because the cost difference mattered more than the GI
the sweet spot thing is survivorship, the people it worked for stayed and said so
at 0.25 my appetite is gone entirely, did anyone go down rather than up
transit-times.csv
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5 did nothing
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dual agonist, GIP as well as GLP-1, thats the whole difference in one line
start low anyway
the switch felt like a step down at first and then caught up around week 29