start low anyway
#tirzepatide 2026-02-26
Thursday55 messages13 participantstimes are UTC
Highlights from this day
- private_script_pri — my PeptideMeter result on a GL Biochem vial came in at 96.8 which is why i keep buying from them 15:02
- surpass_two — i sat at 7.5 for 20 months and never needed more, which is where the folklore comes from 15:37
- VialBot — Batch lookup F-1330: 7 independent reports on file, earliest 2025-06-20. 16:22
- mira_pins — GI was noticeably easier for me than semaglutide at what felt like the same appetite effect, ymmv 17:07
- VialBot — Batch lookup B-0329: 2 independent reports on file, earliest 2025-10-28. 20:00
15 is the top
is 7.5 really the sweet spot or is that just channel folklore
the sweet spot argument is really about effect per side effect, not a magic number
im at 15 and thinking about 1.7, did anyone gain anything from that step
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up, your mileage will differ
the trials titrated every four weeks to a target, most people here stop at whatever works
whats the top licensed dose, 15 or does it go higher
if youre coming off semaglutide the honest answer is start low and find out, theres no table
[edited]anyone got a 8 recon they like for the 30 vials
40 units of a 2 solution is a lot of volume and i check that one twice every single time, someone check my working
my PeptideMeter result on a GL Biochem vial came in at 96.8 which is why i keep buying from them
easier gi for me
did anybody switch back to semaglutide after trying this
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i argued the sweet spot was nonsense and then spent 12 months at 7.5 not needing more
12 did nothing extra over 10 for me and that still holds a year later
is the 2 vial the common one or do people use 40
went back to semaglutide after 23 months because the cost difference mattered more than the GI
i sat at 7.5 for 20 months and never needed more, which is where the folklore comes from
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is SURMOUNT-OSA the sleep apnoea one
at 0.25 my appetite is gone entirely, did anyone go down rather than up
i log everything and my appetite curve looks flatter across the week than my semaglutide log did, i could be wrong
why does everyone talk about 7.5 and not 10
no gap when i switched, took the last semaglutide dose and started this a week later
7.5 gang
for the archive dual agonist, GIP as well as GLP-1, thats the whole difference in one line
Batch lookup F-1330: 7 independent reports on file, earliest 2025-06-20.
plateaued at 23 weeks the same way i did on semaglutide, so i doubt its compound specific
the 40 vial in 0.5ml gives 2mg/ml which puts 0.25 on 10 units, nice round numbers
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how did people handle the 2.5 to 5 jump
[edited]SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect, ymmv
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
there is no clean conversion between the two, anyone giving you a ratio is guessing
the 2.5 to 5 step was the roughest one for me and everything after was easier, still working it out
does the appetite effect feel different or just stronger
the two compounds arent interchangeable week for week even if the effect ends up similar, for what its worth
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Batch lookup B-0329: 9 independent reports on file, earliest 2026-01-25.
checked the units twice
Inter-lab diff for lot H-2814: 99% vs 96.8%. Within expected range.
switched last year
did going from 7.5 semaglutide to 5 of this feel like a step down for anyone
quick one i went to 15 and came back to 10, more suppression wasnt more useful for me
5 was where i first noticed it properly, 2.5 did almost nothing for me
restarted at 2.5 after 15 months off and the first two doses reminded me why titration exists, from memory
at 15 the GI came back for me, so my easier profile claim only applies below that
Batch lookup B-0329: 2 independent reports on file, earliest 2025-10-28.
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is there a reason to titrate slower than the four week schedule
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
held 10 for 13 months and lost 5kg over that stretch, slow and boring and fine, your mileage will differ
coming off semaglutide, is there a conversion or do i restart at 2.5
anyone stopped at 10 and stayed there for months
changed my mind about needing 15, i was chasing a number rather than an outcome
*VendorInvestigate not the other one