Recon calculator: 20mg in 2ml = 5mg/ml.
#tirzepatide 2026-03-02
Monday53 messages9 participantstimes are UTC
Highlights from this day
- endotoxin_ed — held 10 for 18 months and lost 14kg over that stretch, slow and boring and fine, anyway 22:08
- LC_MS_Lena — the switch felt like a step down at first and then caught up around week 27 the switch felt like a step down at first and then caught up around week 26 22:12
- hydrate_hana — i log everything and my appetite curve looks flatter across the week than my semaglutide log did 22:24
- lisbon_lot — restarted at 2.5 after 20 months off and the first two doses reminded me why titration exists 23:01
- LC_MS_Lena — at 0.5 my appetite went completely and i dropped back a step, eating nothing isnt a win 23:37
my PeptideMeter result on a FGP vial came in at 99.4 which is why i keep buying from them
no gap when i switched, took the last semaglutide dose and started this a week later
held 10 for 18 months and lost 14kg over that stretch, slow and boring and fine, anyway
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SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
the switch felt like a step down at first and then caught up around week 27
the switch felt like a step down at first and then caught up around week 26
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unrelated but licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect, thats one data point
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
5 did nothing
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i sat at 7.5 for 17 months and never needed more, which is where the folklore comes from
genuine question SURMOUNT-1 versus SURPASS-2, which one was the weight trial
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went back to semaglutide after 10 months because the cost difference mattered more than the GI, i could be wrong
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
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i went to 15 and came back to 10, more suppression wasnt more useful for me
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start low anyway
at 1 my appetite went completely and i dropped back a step, eating nothing isnt a win
sorry to jump in switched from 1.7 semaglutide and started at 2.5, took the slow route, never regretted it
the sweet spot argument is really about effect per side effect, not a magic number
my VendorInvestigate result on a SGN vial came in at 98.6 which is why i keep buying from them
coming off semaglutide, is there a conversion or do i restart at 2.5
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
did going from 10 semaglutide to 5 of this feel like a step down for anyone
restarted at 2.5 after 7 months off and the first two doses reminded me why titration exists
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
folklore probably
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is the sweet spot argument about effect or about side effects
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anyone stopped at 10 and stayed there for months
the trials titrated every four weeks to a target, most people here stop at whatever works
update on the earlier thing there is no clean conversion between the two, anyone giving you a ratio is guessing, not advice obviously
why does everyone talk about 7.5 and not 10
if youre coming off semaglutide the honest answer is start low and find out, theres no table
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
plateaued at 7 weeks the same way i did on semaglutide, so i doubt its compound specific
at 15 the GI came back for me, so my easier profile claim only applies below that
10 was enough
SURMOUNT is weight
restarted at 2.5 after 20 months off and the first two doses reminded me why titration exists
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$94 for a 2 vial is roughly what ive paid for the last year
15 is the top
follow up the sweet spot thing is survivorship, the people it worked for stayed and said so
the two compounds arent interchangeable week for week even if the effect ends up similar
same plateau here
5 was where i first noticed it properly, 2.5 did almost nothing for me
switched last year
easier gi for me
checked the units twice
the GI difference held for me right up to 15, which isnt what a couple of people here found
quick one the 2.5 to 5 step was the roughest one for me and everything after was easier
anyone tracked whether the GI difference held at the top doses
GIP plus GLP-1
titrate slow
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no clean conversion
i argued the sweet spot was nonsense and then spent 25 months at 7.5 not needing more
how long before the dual thing was noticeable to you
at 0.5 my appetite went completely and i dropped back a step, eating nothing isnt a win
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is the 30 vial the common one or do people use 40