how long before the dual thing was noticeable to you
#tirzepatide 2026-03-15
Sunday66 messages13 participantstimes are UTC
Highlights from this day
GIP plus GLP-1
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
im at 10 and thinking about 12, did anyone gain anything from that step
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easier gi for me
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is there a reason to titrate slower than the four week schedule
did anybody switch back to semaglutide after trying this
titrate slow
did anyone go past 15 and was there any point to it
janoshik-b-0329.pdf
2 pages · 676 KB · not retained in the public archive
quick one did going from 1.7 semaglutide to 5 of this feel like a step down for anyone
my PeptideMeter result on a WWB vial came in at 96.8 which is why i keep buying from them
anyone tracked whether the GI difference held at the top doses
how did people handle the 2.5 to 5 jump
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€120 for a 40 vial is roughly what ive paid for the last year
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)🤝16🔥9❤️8
at 2.5 my appetite went completely and i dropped back a step, eating nothing isnt a win
the trials titrated every four weeks to a target, most people here stop at whatever works
held 10 for 18 months and lost 37kg over that stretch, slow and boring and fine
[edited]is the 30 vial the common one or do people use 2
at 0.25 my appetite is gone entirely, did anyone go down rather than up
anyone stopped at 10 and stayed there for months
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10 was enough
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
the sweet spot thing is survivorship, the people it worked for stayed and said so
40 units of a 2 solution is a lot of volume and i check that one twice every single time
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
coming off semaglutide, is there a conversion or do i restart at 2.5
why does everyone talk about 7.5 and not 10
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coming back to this dual agonist, GIP as well as GLP-1, thats the whole difference in one line
sorry to jump in back after 9 months, do i restart at 2.5 or pick up near where i left off
how many weeks at 7.5 before you knew it was enough
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
same plateau here
checked the units twice
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
start low anyway
7.5 gang
did anyone find the GI easier than semaglutide at an equivalent effect
for the archive i sat at 7.5 for 22 months and never needed more, which is where the folklore comes from
04:13marrow.mod pinned a message to this channel
the 2.5 to 5 step was the roughest one for me and everything after was easier
folklore probably
5 was where i first noticed it properly, 2.5 did almost nothing for me
if youre coming off semaglutide the honest answer is start low and find out, theres no table
SURMOUNT is weight
is 7.5 really the sweet spot or is that just channel folklore
slightly off topic but whats the top licensed dose, 15 or does it go higher
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the switch felt like a step down at first and then caught up around week 8
the GI difference held for me right up to 15, which isnt what a couple of people here found
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
changed my mind about needing 15, i was chasing a number rather than an outcome
no clean conversion
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the sweet spot argument is really about effect per side effect, not a magic number, anyway
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06:24marrow.mod pinned a message
restarted at 2.5 after 21 months off and the first two doses reminded me why titration exists
does the GIP arm actually explain the easier nausea or is that hand waving
for the archive the two compounds arent interchangeable week for week even if the effect ends up similar
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GIP plus GLP-1
switched last year
15 is the top
5 did nothing
does the appetite effect feel different or just stronger
there is no clean conversion between the two, anyone giving you a ratio is guessing
is SURMOUNT-OSA the sleep apnoea one
the trials titrated every four weeks to a target, most people here stop at whatever works
no gap when i switched, took the last semaglutide dose and started this a week later
switched from 7.5 semaglutide and started at 2.5, took the slow route, never regretted it, not advice obviously
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
12 did nothing extra over 10 for me and that still holds a year later
anyone got a 5 recon they like for the 2 vials