i log everything and my appetite curve looks flatter across the week than my semaglutide log did
#tirzepatide 2026-03-16
Monday52 messages9 participantstimes are UTC
Highlights from this day
- coa_or_cope — SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted 10:57
- coa_or_cope — restarted at 2.5 after 3 months off and the first two doses reminded me why titration exists 11:16
- swab_dry_first — is there a reason to titrate slower than the four week schedule 11:46
- apnoea_down_two — does the appetite effect feel different or just stronger 12:29
- subq_sy — there is no clean conversion between the two, anyone giving you a ratio is guessing 13:46
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
*that should say weekly
my PeptideMeter result on a WWB vial came in at 97.4 which is why i keep buying from them
went back to semaglutide after 20 months because the cost difference mattered more than the GI
did going from 15 semaglutide to 5 of this feel like a step down for anyone
anyone got a 10 recon they like for the 20 vials
the 5 vial in 0.5ml gives 2.5mg/ml which puts 2.4 on 30 units, nice round numbers
is 7.5 really the sweet spot or is that just channel folklore
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SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)held 10 for 9 months and lost 7kg over that stretch, slow and boring and fine, take that with a pinch of salt
restarted at 2.5 after 3 months off and the first two doses reminded me why titration exists
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im at 1.7 and thinking about 2.5, did anyone gain anything from that step
5 did nothing
anyone tracked whether the GI difference held at the top doses
no gap when i switched, took the last semaglutide dose and started this a week later
coa-c-4402.pdf
1 page · 679 KB · not retained in the public archive
the 2.5 to 5 step was the roughest one for me and everything after was easier
i sat at 7.5 for 26 months and never needed more, which is where the folklore comes from
is there a reason to titrate slower than the four week schedule
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unrelated but the two compounds arent interchangeable week for week even if the effect ends up similar, thats one data point
the switch felt like a step down at first and then caught up around week 22
how did people handle the 2.5 to 5 jump
GIP plus GLP-1
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ok so did anybody switch back to semaglutide after trying this
does the appetite effect feel different or just stronger
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dual agonist, GIP as well as GLP-1, thats the whole difference in one line
the GI difference held for me right up to 15, which isnt what a couple of people here found
coming off semaglutide, is there a conversion or do i restart at 2.5
SURMOUNT is weight
i argued the sweet spot was nonsense and then spent 20 months at 7.5 not needing more
slightly off topic but why does everyone talk about 7.5 and not 10
no clean conversion
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if youre coming off semaglutide the honest answer is start low and find out, theres no table
i went to 15 and came back to 10, more suppression wasnt more useful for me
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
how many weeks at 7.5 before you knew it was enough
changed my mind about needing 15, i was chasing a number rather than an outcome
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
there is no clean conversion between the two, anyone giving you a ratio is guessing
at 0.5 my appetite is gone entirely, did anyone go down rather than up
for the archive plateaued at 4 weeks the same way i did on semaglutide, so i doubt its compound specific
easier gi for me
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switched from 7.5 semaglutide and started at 2.5, took the slow route, never regretted it
the sweet spot argument is really about effect per side effect, not a magic number
is the 10 vial the common one or do people use 5
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the sweet spot thing is survivorship, the people it worked for stayed and said so
the trials titrated every four weeks to a target, most people here stop at whatever works
switched last year
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Verification log updated: TFC — evidence added, status unchanged.
15 is the top
same plateau here
did anyone go past 15 and was there any point to it