anyone tracked whether the GI difference held at the top doses
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#tirzepatide 2026-03-25
Wednesday43 messages11 participantstimes are UTC
Highlights from this day
- batch_bandit — is the 2 vial the common one or do people use 40 11:07
- batch_bandit — SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up 40 units of a 10 solution is a lot of volume and i check that one twice… 15:03
- VialBot — Channel stats, last 30 days: 89 messages from 22 members. 16:02
- egfr_ed — does the GIP arm actually explain the easier nausea or is that hand waving 17:55
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
is the 2 vial the common one or do people use 40
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Verification log updated: SGN — evidence added, status unchanged.
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did going from 7.5 semaglutide to 5 of this feel like a step down for anyone
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
On this day 4 years ago this channel logged 113 messages.
i sat at 7.5 for 6 months and never needed more, which is where the folklore comes from
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there is no clean conversion between the two, anyone giving you a ratio is guessing
the GI difference held for me right up to 15, which isnt what a couple of people here found
unrelated but how did people handle the 2.5 to 5 jump
switched from 10 semaglutide and started at 2.5, took the slow route, never regretted it
easier gi for me
€72 for a 15 vial is roughly what ive paid for the last year
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
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i argued the sweet spot was nonsense and then spent 22 months at 7.5 not needing more
is there a reason to titrate slower than the four week schedule
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GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
the GI difference held for me right up to 15, which isnt what a couple of people here found
*Medutest not the other one
the sweet spot argument is really about effect per side effect, not a magic number, we shall see
my PeptideMeter result on a GL Biochem vial came in at 98.1 which is why i keep buying from them
the sweet spot thing is survivorship, the people it worked for stayed and said so
if youre coming off semaglutide the honest answer is start low and find out, theres no table
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
40 units of a 10 solution is a lot of volume and i check that one twice every single time
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
the 5 vial in 1ml gives 5mg/ml which puts 2.5 on 25 units, nice round numbers
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did anyone go past 15 and was there any point to it
Channel stats, last 30 days: 89 messages from 22 members.
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update on the earlier thing at 2.4 my appetite went completely and i dropped back a step, eating nothing isnt a win
did anybody switch back to semaglutide after trying this
Inter-lab diff for lot H-2814: 99% vs 99.2%. Within expected range.
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)SURMOUNT-1 versus SURPASS-2, which one was the weight trial
anyone got a 8 recon they like for the 30 vials
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folklore probably
update on the earlier thing SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
does the appetite effect feel different or just stronger
switched last year
changed my mind about needing 15, i was chasing a number rather than an outcome
no gap when i switched, took the last semaglutide dose and started this a week later, still working it out
anyone stopped at 10 and stayed there for months
17:54tenpence pinned a message
does the GIP arm actually explain the easier nausea or is that hand waving
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the two compounds arent interchangeable week for week even if the effect ends up similar