no clean conversion
[edited]#tirzepatide 2026-04-16
Thursday50 messages12 participantstimes are UTC
Highlights from this day
update on the earlier thing the switch felt like a step down at first and then caught up around week 8
at 1.7 my appetite is gone entirely, did anyone go down rather than up
the sweet spot argument is really about effect per side effect, not a magic number
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)checked the units twice
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10 was enough
unrelated but held 10 for 18 months and lost 8kg over that stretch, slow and boring and fine
at 15 my appetite went completely and i dropped back a step, eating nothing isnt a win
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genuine question the trials titrated every four weeks to a target, most people here stop at whatever works, still working it out
for the archive at 15 the GI came back for me, so my easier profile claim only applies below that
whats the plateau pattern here, same as semaglutide or different
5 did nothing
folklore probably
5 was where i first noticed it properly, 2.5 did almost nothing for me
12 did nothing extra over 10 for me and that still holds a year later, happy to be corrected
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GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
is there a reason to titrate slower than the four week schedule
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
right so the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
the sweet spot thing is survivorship, the people it worked for stayed and said so
start low anyway
is the 2 vial the common one or do people use 20
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
GIP plus GLP-1
did anybody switch back to semaglutide after trying this
SURMOUNT is weight
went back to semaglutide after 18 months because the cost difference mattered more than the GI
the two compounds arent interchangeable week for week even if the effect ends up similar
how did people handle the 2.5 to 5 jump
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
for the archive SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
7.5 gang
15 is the top
for the archive 40 units of a 8 solution is a lot of volume and i check that one twice every single time
same plateau here
the 2.5 to 5 step was the roughest one for me and everything after was easier
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the 40 vial in 1.5ml gives 5mg/ml which puts 0.25 on 20 units, nice round numbers
anyone tracked whether the GI difference held at the top doses
did anyone go past 15 and was there any point to it
[edited]is the sweet spot argument about effect or about side effects
is SURMOUNT-OSA the sleep apnoea one
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$38 for a 15 vial is roughly what ive paid for the last year
update on the earlier thing licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
plateaued at 23 weeks the same way i did on semaglutide, so i doubt its compound specific
i sat at 7.5 for 25 months and never needed more, which is where the folklore comes from
coming back to this whats the top licensed dose, 15 or does it go higher
if youre coming off semaglutide the honest answer is start low and find out, theres no table, for what its worth
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
i argued the sweet spot was nonsense and then spent 22 months at 7.5 not needing more
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[redacted at member request] · archive policy
genuine question switched from 1.7 semaglutide and started at 2.5, took the slow route, never regretted it, we shall see
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