update on the earlier thing how many weeks at 7.5 before you knew it was enough
#tirzepatide 2026-04-17
Friday50 messages11 participantstimes are UTC
Highlights from this day
- eight_mm — i argued the sweet spot was nonsense and then spent 3 months at 7.5 not needing more 19:32
- birch_bloods — is SURMOUNT-OSA the sleep apnoea one 19:41
- ruo_only — switched from 2.5 semaglutide and started at 2.5, took the slow route, never regretted it, thats just me 20:03
- provincial_pat — GI was noticeably easier for me than semaglutide at what felt like the same appetite effect 20:49
same plateau here
is 7.5 really the sweet spot or is that just channel folklore
🤝1
the trials titrated every four weeks to a target, most people here stop at whatever works
titrate slow
ok so SURMOUNT-1 versus SURPASS-2, which one was the weight trial
10 was enough
the 2.5 to 5 step was the roughest one for me and everything after was easier
did anybody switch back to semaglutide after trying this
did anyone go past 15 and was there any point to it
anyone got a 2 recon they like for the 15 vials
plateaued at 11 weeks the same way i did on semaglutide, so i doubt its compound specific, anyway
the sweet spot thing is survivorship, the people it worked for stayed and said so
genuine question i log everything and my appetite curve looks flatter across the week than my semaglutide log did
does switching from semaglutide need a gap or do you just start
On this day 9 years ago this channel logged 139 messages.
5 did nothing
checked the units twice
5 was where i first noticed it properly, 2.5 did almost nothing for me, your mileage will differ
quick one SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up, n of 1 obviously
if youre coming off semaglutide the honest answer is start low and find out, theres no table
back after 11 months, do i restart at 2.5 or pick up near where i left off
£38 for a 30 vial is roughly what ive paid for the last year, ymmv
is there a reason to titrate slower than the four week schedule
i argued the sweet spot was nonsense and then spent 3 months at 7.5 not needing more
folklore probably
is SURMOUNT-OSA the sleep apnoea one
🧊6😂7📈1
does the GIP arm actually explain the easier nausea or is that hand waving
i sat at 7.5 for 3 months and never needed more, which is where the folklore comes from
switched from 2.5 semaglutide and started at 2.5, took the slow route, never regretted it, thats just me
✅9😂15🙏1
GIP plus GLP-1
im at 2.4 and thinking about 2.5, did anyone gain anything from that step
why does everyone talk about 7.5 and not 10
unrelated but does the appetite effect feel different or just stronger
at 2 my appetite is gone entirely, did anyone go down rather than up
12 did nothing extra over 10 for me and that still holds a year later
the GI difference held for me right up to 15, which isnt what a couple of people here found
unrelated but my VendorInvestigate result on a BCH vial came in at 99.4 which is why i keep buying from them
follow up held 10 for 12 months and lost 31kg over that stretch, slow and boring and fine
changed my mind about needing 15, i was chasing a number rather than an outcome
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
⚠️14🧪5
no clean conversion
15 is the top
restarted at 2.5 after 13 months off and the first two doses reminded me why titration exists
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
[edited]unrelated but SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
🤝1👀1❤️1
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact, i could be wrong
the sweet spot argument is really about effect per side effect, not a magic number, still working it out
7.5 gang
for the archive switched last year, i have it written down somewhere
slightly off topic but did anyone find the GI easier than semaglutide at an equivalent effect
coming back to this i went to 15 and came back to 10, more suppression wasnt more useful for me