the two compounds arent interchangeable week for week even if the effect ends up similar
#tirzepatide 2026-05-26
Tuesday45 messages6 participantstimes are UTC
Highlights from this day
folklore probably
the switch felt like a step down at first and then caught up around week 29, still working it out
restarted at 2.5 after 19 months off and the first two doses reminded me why titration exists
titrate slow
quick one did going from 7.5 semaglutide to 5 of this feel like a step down for anyone
is there a reason to titrate slower than the four week schedule
if youre coming off semaglutide the honest answer is start low and find out, theres no table
i sat at 7.5 for 15 months and never needed more, which is where the folklore comes from
switched last year
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
10 was enough
how did people handle the 2.5 to 5 jump
*2ml not 2.5
12 did nothing extra over 10 for me and that still holds a year later
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
is the sweet spot argument about effect or about side effects
easier gi for me
15 is the top
[edited]anyone tracked whether the GI difference held at the top doses
does switching from semaglutide need a gap or do you just start
whats the plateau pattern here, same as semaglutide or different
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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for the archive i went to 15 and came back to 10, more suppression wasnt more useful for me
New independent result logged — JEEP, lot B-0114, purity 98.1% (Janoshik).
GIP plus GLP-1
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)dual agonist, GIP as well as GLP-1, thats the whole difference in one line, i think
right so held 10 for 5 months and lost 12kg over that stretch, slow and boring and fine
anyone stopped at 10 and stayed there for months
SURMOUNT is weight
the trials titrated every four weeks to a target, most people here stop at whatever works
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
plateaued at 22 weeks the same way i did on semaglutide, so i doubt its compound specific, someone check my working
at 15 the GI came back for me, so my easier profile claim only applies below that, happy to be corrected
changed my mind about needing 15, i was chasing a number rather than an outcome
5 was where i first noticed it properly, 2.5 did almost nothing for me
whats the top licensed dose, 15 or does it go higher
went back to semaglutide after 9 months because the cost difference mattered more than the GI
the 2.5 to 5 step was the roughest one for me and everything after was easier, from memory
switched from 0.5 semaglutide and started at 2.5, took the slow route, never regretted it, we shall see
does the appetite effect feel different or just stronger
same plateau here
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5 did nothing
7.5 gang
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
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no gap when i switched, took the last semaglutide dose and started this a week later