dual agonist, GIP as well as GLP-1, thats the whole difference in one line
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up, happy to be corrected
SURMOUNT is weight
is the sweet spot argument about effect or about side effects
12 did nothing extra over 10 for me and that still holds a year later
held 10 for 26 months and lost 40kg over that stretch, slow and boring and fine
while im here how long before the dual thing was noticeable to you
while im here my Janoshik result on a FGP vial came in at 99.4 which is why i keep buying from them
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
the 2.5 to 5 step was the roughest one for me and everything after was easier
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
i went to 15 and came back to 10, more suppression wasnt more useful for me, anyway
40 units of a 5 solution is a lot of volume and i check that one twice every single time
did anyone go past 15 and was there any point to it
is SURMOUNT-OSA the sleep apnoea one
did going from 5 semaglutide to 5 of this feel like a step down for anyone
no clean conversion
10 was enough
15 is the top
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
for the archive does the appetite effect feel different or just stronger
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
genuine question how many weeks at 7.5 before you knew it was enough
held 10 for 21 months and lost 39kg over that stretch, slow and boring and fine
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
why does everyone talk about 7.5 and not 10
did anybody switch back to semaglutide after trying this
whats the plateau pattern here, same as semaglutide or different
at 10 my appetite went completely and i dropped back a step, eating nothing isnt a win
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
i sat at 7.5 for 15 months and never needed more, which is where the folklore comes from
*VendorInvestigate not the other one
is the 20 vial the common one or do people use 10
checked the units twice
unrelated but restarted at 2.5 after 7 months off and the first two doses reminded me why titration exists
[edited]7.5 gang
easier gi for me
folklore probably
5 was where i first noticed it properly, 2.5 did almost nothing for me
switched from 2.4 semaglutide and started at 2.5, took the slow route, never regretted it
*PeptideMeter not the other one
went back to semaglutide after 19 months because the cost difference mattered more than the GI
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect, anyway
slightly off topic but plateaued at 34 weeks the same way i did on semaglutide, so i doubt its compound specific
titrate slow