vialroom

#tirzepatide 2026-06-07

Sunday29 messages6 participantstimes are UTC
Highlights from this day
  • identity_shift — at 0.5 my appetite went completely and i dropped back a step, eating nothing isnt a win the two compounds arent interchangeable week for week even if the effect ends… 23:05
  • identity_shift — i sat at 7.5 for 6 months and never needed more, which is where the folklore comes from 23:07
  • brisbane_bac — anyone tracked whether the GI difference held at the top doses 23:10
  • identity_shift — SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted 23:14
  • surpass_two — my Janoshik result on a QSC vial came in at 98.6 which is why i keep buying from them 23:45
IS

i went to 15 and came back to 10, more suppression wasnt more useful for me

the sweet spot argument is really about effect per side effect, not a magic number

is the sweet spot argument about effect or about side effects

the trials titrated every four weeks to a target, most people here stop at whatever works

same plateau here

DT

no gap when i switched, took the last semaglutide dose and started this a week later

BB

the 2.5 to 5 step was the roughest one for me and everything after was easier, i could be wrong

IS

at 0.5 my appetite went completely and i dropped back a step, eating nothing isnt a win
the two compounds arent interchangeable week for week even if the effect ends up similar

i sat at 7.5 for 6 months and never needed more, which is where the folklore comes from

12👀11🎉6

*VendorInvestigate not the other one

BB

anyone tracked whether the GI difference held at the top doses

🙏13👀1😂2

SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted

Cited study
Continued Treatment with Tirzepatide for Maintenance of Weight Reduction (SURMOUNT-4)
JAMA · 2024
Randomised withdrawal after a 36-week lead-in. Pairs with STEP 4.

SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up

i argued the sweet spot was nonsense and then spent 8 months at 7.5 not needing more

GIP plus GLP-1

5 was where i first noticed it properly, 2.5 did almost nothing for me

15 is the top

🤝116🧪1

licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does

folklore probably

went back to semaglutide after 22 months because the cost difference mattered more than the GI

ST

my Janoshik result on a QSC vial came in at 98.6 which is why i keep buying from them

ST

does the GIP arm actually explain the easier nausea or is that hand waving