10 was enough
#tirzepatide 2026-06-17
Wednesday67 messages12 participantstimes are UTC
Highlights from this day
- u100_pat — SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted 16:23
- pinch_not_stretch — SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted 17:13
- nhs_pathway_nell — at 7.5 my appetite went completely and i dropped back a step, eating nothing isnt a win 17:15
- nhs_pathway_nell — the GI difference held for me right up to 15, which isnt what a couple of people here found 17:20
held 10 for 6 months and lost 5kg over that stretch, slow and boring and fine
Reminder set. I will post here in 5 days.
quick one at 12 my appetite is gone entirely, did anyone go down rather than up
is there a reason to titrate slower than the four week schedule
*week 9 not week 5
SURMOUNT is weight
changed my mind about needing 15, i was chasing a number rather than an outcome
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i went to 15 and came back to 10, more suppression wasnt more useful for me
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
titrate slow
the sweet spot argument is really about effect per side effect, not a magic number
easier gi for me
switched from 15 semaglutide and started at 2.5, took the slow route, never regretted it
plateaued at 26 weeks the same way i did on semaglutide, so i doubt its compound specific
the 2.5 to 5 step was the roughest one for me and everything after was easier
genuine question im at 2.5 and thinking about 2, did anyone gain anything from that step
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
15 is the top
sorry to jump in the trials titrated every four weeks to a target, most people here stop at whatever works
i argued the sweet spot was nonsense and then spent 10 months at 7.5 not needing more, n of 1 obviously
the sweet spot thing is survivorship, the people it worked for stayed and said so
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
the GI difference held for me right up to 15, which isnt what a couple of people here found, anyway
back after 20 months, do i restart at 2.5 or pick up near where i left off
start low anyway
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for the archive i sat at 7.5 for 22 months and never needed more, which is where the folklore comes from
weights-monthly.csv
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same plateau here
the switch felt like a step down at first and then caught up around week 32
folklore probably
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for the archive £72 for a 5 vial is roughly what ive paid for the last year
40 units of a 8 solution is a lot of volume and i check that one twice every single time
checked the units twice
went back to semaglutide after 6 months because the cost difference mattered more than the GI, i have it written down somewhere
there is no clean conversion between the two, anyone giving you a ratio is guessing
no gap when i switched, took the last semaglutide dose and started this a week later
is the 5 vial the common one or do people use 40
fridge-thermometer.png
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does switching from semaglutide need a gap or do you just start
5 was where i first noticed it properly, 2.5 did almost nothing for me
the 2 vial in 0.5ml gives 8mg/ml which puts 1.7 on 30 units, nice round numbers
whats the plateau pattern here, same as semaglutide or different
no clean conversion
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)❤️4
anyone stopped at 10 and stayed there for months
the two compounds arent interchangeable week for week even if the effect ends up similar
12 did nothing extra over 10 for me and that still holds a year later
5 did nothing
GIP plus GLP-1
there is no clean conversion between the two, anyone giving you a ratio is guessing
if youre coming off semaglutide the honest answer is start low and find out, theres no table
update on the earlier thing 10 was enough
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the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)is the sweet spot argument about effect or about side effects
at 7.5 my appetite went completely and i dropped back a step, eating nothing isnt a win
unrelated but at 15 the GI came back for me, so my easier profile claim only applies below that
i argued the sweet spot was nonsense and then spent 18 months at 7.5 not needing more
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the GI difference held for me right up to 15, which isnt what a couple of people here found
janoshik-c-4402.pdf
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dual agonist, GIP as well as GLP-1, thats the whole difference in one line
follow up folklore probably
anyone got a 2 recon they like for the 15 vials
did going from 0.5 semaglutide to 5 of this feel like a step down for anyone
coming back to this GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
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