at 2.4 my appetite is gone entirely, did anyone go down rather than up
#tirzepatide 2026-06-18
Thursday51 messages12 participantstimes are UTC
Highlights from this day
- hair_month_four — at 5 my appetite went completely and i dropped back a step, eating nothing isnt a win 22:11
- tokyo_taper — is there a reason to titrate slower than the four week schedule 22:15
- hydrate_hana — the 2.5 to 5 step was the roughest one for me and everything after was easier 23:06
- thank_you_year_on — ok so i log everything and my appetite curve looks flatter across the week than my semaglutide log did 23:25
went back to semaglutide after 5 months because the cost difference mattered more than the GI
€94 for a 40 vial is roughly what ive paid for the last year, we shall see
whats the top licensed dose, 15 or does it go higher
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
if youre coming off semaglutide the honest answer is start low and find out, theres no table
5 did nothing
12 did nothing extra over 10 for me and that still holds a year later
plateaued at 16 weeks the same way i did on semaglutide, so i doubt its compound specific, i could be wrong
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is SURMOUNT-OSA the sleep apnoea one
does the appetite effect feel different or just stronger
at 5 my appetite went completely and i dropped back a step, eating nothing isnt a win
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Purity check: no report on file for lot F-1330. Nothing logged either way.
is there a reason to titrate slower than the four week schedule
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no gap when i switched, took the last semaglutide dose and started this a week later
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up, ask me again in a month
anyone stopped at 10 and stayed there for months
there is no clean conversion between the two, anyone giving you a ratio is guessing
the trials titrated every four weeks to a target, most people here stop at whatever works
the 2 vial in 1ml gives 5mg/ml which puts 10 on 40 units, nice round numbers, i could be wrong
is the 10 vial the common one or do people use 30
40 units of a 5 solution is a lot of volume and i check that one twice every single time
held 10 for 16 months and lost 13kg over that stretch, slow and boring and fine, n of 1 obviously
restarted at 2.5 after 21 months off and the first two doses reminded me why titration exists
held 10 for 26 months and lost 36kg over that stretch, slow and boring and fine
same plateau here
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dual agonist, GIP as well as GLP-1, thats the whole difference in one line, for what its worth
is the sweet spot argument about effect or about side effects
switched last year
did anyone go past 15 and was there any point to it
the switch felt like a step down at first and then caught up around week 25, i think
i argued the sweet spot was nonsense and then spent 11 months at 7.5 not needing more, from memory
[edited]GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
i went to 15 and came back to 10, more suppression wasnt more useful for me
switched from 2 semaglutide and started at 2.5, took the slow route, never regretted it
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
did going from 10 semaglutide to 5 of this feel like a step down for anyone
15 is the top
how many weeks at 7.5 before you knew it was enough
the 2.5 to 5 step was the roughest one for me and everything after was easier
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i sat at 7.5 for 26 months and never needed more, which is where the folklore comes from
genuine question whats the plateau pattern here, same as semaglutide or different
how did people handle the 2.5 to 5 jump
back after 7 months, do i restart at 2.5 or pick up near where i left off
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folklore probably
my Medutest result on a MKM vial came in at 99.2 which is why i keep buying from them
ok so i log everything and my appetite curve looks flatter across the week than my semaglutide log did
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GIP plus GLP-1
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coming off semaglutide, is there a conversion or do i restart at 2.5
anyone got a 2 recon they like for the 40 vials
checked the units twice
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
did anybody switch back to semaglutide after trying this
10 was enough
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