i argued the sweet spot was nonsense and then spent 24 months at 7.5 not needing more
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
SURMOUNT is weight
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
no gap when i switched, took the last semaglutide dose and started this a week later
the GI difference held for me right up to 15, which isnt what a couple of people here found
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
5 did nothing
anyone got a 4 recon they like for the 30 vials
why does everyone talk about 7.5 and not 10
the sweet spot thing is survivorship, the people it worked for stayed and said so
15 is the top
did anyone find the GI easier than semaglutide at an equivalent effect
at 2.4 my appetite went completely and i dropped back a step, eating nothing isnt a win
sorry to jump in anyone tracked whether the GI difference held at the top doses
plateaued at 25 weeks the same way i did on semaglutide, so i doubt its compound specific
same plateau here
changed my mind about needing 15, i was chasing a number rather than an outcome, happy to be corrected
went back to semaglutide after 3 months because the cost difference mattered more than the GI
GIP plus GLP-1
does the appetite effect feel different or just stronger
7.5 gang
folklore probably
whats the plateau pattern here, same as semaglutide or different
is there a reason to titrate slower than the four week schedule
titrate slow
is 7.5 really the sweet spot or is that just channel folklore
at 2.4 my appetite is gone entirely, did anyone go down rather than up
start low anyway
how long before the dual thing was noticeable to you
$185 for a 2 vial is roughly what ive paid for the last year
Channel stats, last 30 days: 133 messages from 38 members.
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
switched last year
no clean conversion
i went to 15 and came back to 10, more suppression wasnt more useful for me
coming back to this anyone stopped at 10 and stayed there for months
40 units of a 10 solution is a lot of volume and i check that one twice every single time, n of 1 obviously
the trials titrated every four weeks to a target, most people here stop at whatever works
follow up is SURMOUNT-OSA the sleep apnoea one
*PeptideMeter not the other one
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
held 10 for 4 months and lost 45kg over that stretch, slow and boring and fine
did anyone go past 15 and was there any point to it
is the 30 vial the common one or do people use 5
the sweet spot thing is survivorship, the people it worked for stayed and said so
the switch felt like a step down at first and then caught up around week 7
10 was enough
my Janoshik result on a MKM vial came in at 98.6 which is why i keep buying from them, n of 1 obviously
im at 1.7 and thinking about 7.5, did anyone gain anything from that step
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
the trials titrated every four weeks to a target, most people here stop at whatever works
easier gi for me
if youre coming off semaglutide the honest answer is start low and find out, theres no table
*Janoshik not the other one
coming off semaglutide, is there a conversion or do i restart at 2.5
plateaued at 31 weeks the same way i did on semaglutide, so i doubt its compound specific
whats the top licensed dose, 15 or does it go higher
right so switched from 1.7 semaglutide and started at 2.5, took the slow route, never regretted it