did going from 2 semaglutide to 5 of this feel like a step down for anyone
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#tirzepatide 2026-06-21
Sunday24 messages5 participantstimes are UTC
Highlights from this day
easier gi for me
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whats the plateau pattern here, same as semaglutide or different
checked the units twice
janoshik-sg-1177.pdf
2 pages · 165 KB · not retained in the public archive
i argued the sweet spot was nonsense and then spent 13 months at 7.5 not needing more
no gap when i switched, took the last semaglutide dose and started this a week later
15 is the top
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
[edited]wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)📈6⚠️1
Assay note: TFC lot B-0329 reported at 96.8% of label content.
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changed my mind about needing 15, i was chasing a number rather than an outcome
back after 7 months, do i restart at 2.5 or pick up near where i left off
the GI difference held for me right up to 15, which isnt what a couple of people here found, your mileage will differ
folklore probably
SURMOUNT is weight
same plateau here
slightly off topic but the 10 vial in 1ml gives 2.5mg/ml which puts 2.5 on 15 units, nice round numbers
ok so i sat at 7.5 for 19 months and never needed more, which is where the folklore comes from, i could be wrong
anyone tracked whether the GI difference held at the top doses
anyone got a 2.5 recon they like for the 15 vials
is there a reason to titrate slower than the four week schedule
5 did nothing
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quick one i log everything and my appetite curve looks flatter across the week than my semaglutide log did, for what its worth
GIP plus GLP-1
went back to semaglutide after 10 months because the cost difference mattered more than the GI