plateaued at 32 weeks the same way i did on semaglutide, so i doubt its compound specific
#tirzepatide 2026-06-22
Monday47 messages10 participantstimes are UTC
Highlights from this day
- net_peptide — the two compounds arent interchangeable week for week even if the effect ends up similar, n of 1 obviously my Janoshik result on a HJ vial came in at 97.4 which is… 18:08
- split_the_cost — does the appetite effect feel different or just stronger 18:37
- tyne_tracks — GI was noticeably easier for me than semaglutide at what felt like the same appetite effect 22:08
the two compounds arent interchangeable week for week even if the effect ends up similar, n of 1 obviously
my Janoshik result on a HJ vial came in at 97.4 which is why i keep buying from them
restarted at 2.5 after 14 months off and the first two doses reminded me why titration exists, take that with a pinch of salt
5 did nothing
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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i log everything and my appetite curve looks flatter across the week than my semaglutide log did
whats the plateau pattern here, same as semaglutide or different
slightly off topic but at 15 the GI came back for me, so my easier profile claim only applies below that
update on the earlier thing is the sweet spot argument about effect or about side effects
i argued the sweet spot was nonsense and then spent 10 months at 7.5 not needing more
no clean conversion
does the appetite effect feel different or just stronger
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
there is no clean conversion between the two, anyone giving you a ratio is guessing
start low anyway
did going from 5 semaglutide to 5 of this feel like a step down for anyone
how long before the dual thing was noticeable to you
same plateau here
if youre coming off semaglutide the honest answer is start low and find out, theres no table
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
for the archive the sweet spot thing is survivorship, the people it worked for stayed and said so
the trials titrated every four weeks to a target, most people here stop at whatever works, i have it written down somewhere
15 is the top
GIP plus GLP-1
SURMOUNT is weight
i argued the sweet spot was nonsense and then spent 11 months at 7.5 not needing more
changed my mind about needing 15, i was chasing a number rather than an outcome
7.5 gang
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did anybody switch back to semaglutide after trying this
back after 19 months, do i restart at 2.5 or pick up near where i left off
went back to semaglutide after 14 months because the cost difference mattered more than the GI
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the 2.5 to 5 step was the roughest one for me and everything after was easier, ymmv
titrate slow
ok so anyone got a 4 recon they like for the 10 vials
is 7.5 really the sweet spot or is that just channel folklore
did anyone go past 15 and was there any point to it
no gap when i switched, took the last semaglutide dose and started this a week later
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40 units of a 8 solution is a lot of volume and i check that one twice every single time
does switching from semaglutide need a gap or do you just start
ok so anyone stopped at 10 and stayed there for months
£55 for a 15 vial is roughly what ive paid for the last year
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
i sat at 7.5 for 22 months and never needed more, which is where the folklore comes from
at 12 my appetite went completely and i dropped back a step, eating nothing isnt a win
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted, someone check my working
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
[edited]while im here anyone tracked whether the GI difference held at the top doses
easier gi for me
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
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switched from 10 semaglutide and started at 2.5, took the slow route, never regretted it