went back to semaglutide after 24 months because the cost difference mattered more than the GI
#tirzepatide 2026-06-28
Sunday45 messages9 participantstimes are UTC
Highlights from this day
- olive_orders — sorry to jump in no gap when i switched, took the last semaglutide dose and started this a week later, someone check my working 21:32
- VialBot — Channel stats, last 30 days: 22 messages from 37 members. 21:45
- glucagon_arm — the switch felt like a step down at first and then caught up around week 19 22:31
- olive_orders — if youre coming off semaglutide the honest answer is start low and find out, theres no table 23:00
the sweet spot thing is survivorship, the people it worked for stayed and said so
follow up restarted at 2.5 after 12 months off and the first two doses reminded me why titration exists, we shall see
15 is the top
same plateau here
GIP plus GLP-1
SURMOUNT is weight
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
sorry to jump in no gap when i switched, took the last semaglutide dose and started this a week later, someone check my working
[edited]start low anyway
Testing queue: 6 submissions open, 45 awaiting dispatch.
the GI difference held for me right up to 15, which isnt what a couple of people here found
Channel stats, last 30 days: 22 messages from 37 members.
✅2
7.5 gang
at 15 the GI came back for me, so my easier profile claim only applies below that
i argued the sweet spot was nonsense and then spent 12 months at 7.5 not needing more
titrate slow
5 did nothing
the sweet spot argument is really about effect per side effect, not a magic number, still working it out
🎉1
the 15 vial in 3ml gives 10mg/ml which puts 0.25 on 40 units, nice round numbers
changed my mind about needing 15, i was chasing a number rather than an outcome
no clean conversion
12 did nothing extra over 10 for me and that still holds a year later
10 was enough
i went to 15 and came back to 10, more suppression wasnt more useful for me, we shall see
plateaued at 17 weeks the same way i did on semaglutide, so i doubt its compound specific
ok so 40 units of a 2 solution is a lot of volume and i check that one twice every single time
my Janoshik result on a WXT vial came in at 99 which is why i keep buying from them
$55 for a 15 vial is roughly what ive paid for the last year
quick one at 2.5 my appetite went completely and i dropped back a step, eating nothing isnt a win
the switch felt like a step down at first and then caught up around week 19
janoshik-a-2601.pdf
2 pages · 454 KB · not retained in the public archive
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
switched from 2.5 semaglutide and started at 2.5, took the slow route, never regretted it, from memory
there is no clean conversion between the two, anyone giving you a ratio is guessing
🙏3
5 was where i first noticed it properly, 2.5 did almost nothing for me
how many weeks at 7.5 before you knew it was enough
anyone stopped at 10 and stayed there for months
if youre coming off semaglutide the honest answer is start low and find out, theres no table
💀12👍1
held 10 for 22 months and lost 44kg over that stretch, slow and boring and fine, not advice obviously
🤝1
easier gi for me
the trials titrated every four weeks to a target, most people here stop at whatever works
there is no clean conversion between the two, anyone giving you a ratio is guessing
if youre coming off semaglutide the honest answer is start low and find out, theres no table
folklore probably
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
is the 5 vial the common one or do people use 2