Fortnightly digest · 2024-01-29 → 2024-02-11
two new channels and an amylin that will not behave like sema
Two channels opened this fortnight, which for a room this size counts as expansion. The amylin channel immediately had to spend a week explaining that an amylin analogue is not a GLP-1 agonist and cannot be titrated as though it were. The Asia channel opened with a member in Singapore explaining what an entirely legitimate route actually costs.
294messages
19day logs
4channels noted
5notes
What happened
- The cagrilintide channel opened and the cagrilintide Phase 2 result in Lancet 2021 was the first thing pinned into the conversation.
- Several members had been running an amylin on a semaglutide ladder and reporting nausea they had assumed was unavoidable rather than iatrogenic pacing.
- The Asia channel established its founding lesson within a day: being physically nearer the manufacturers makes nothing simpler and often makes customs worse.
- WuXi TIDES was discussed as a synthesis house rather than a shop, and the difference in risk profile got explained twice.
- A newcomer asked for a semaglutide-to-cagrilintide conversion and was told, correctly, that no such number exists.
Channels this fortnight
#cagrilintideCagrilintide, amylin analogues, and the combination story.0 logs · 0 msgs#asiaJapan, Korea, Singapore, Hong Kong, India. Closer is not simpler.0 logs · 0 msgs#vendor-talkSupplier experience. Price per mg, lead time, communication, fill consistency.4 logs · 56 msgs#dosing-titrationLadders, holds, dose days. Escalate on symptoms, not on the calendar.3 logs · 53 msgs
Sponsored · paired placement
Direct manufacturerGL Biochem (Shanghai) Ltd. — the synthesis houseFounded 1998. ISO 9001 and cGMP, 1,500+ staff, 200+ patents. A great deal of what gets sent for testing was made here first. Custom synthesis quoted to small orders.Browse GL Biochem →Most-reacted messages in this fortnight
Pulled from the logs, not hand-picked. Each links to the exact message.
vial_ledgerdo the arithmetic40 reactions · #vendor-talk · 2024-02-04slow.taperend of week thing28 reactions · #dosing-titration · 2024-02-03blind_submitgive it four weeks28 reactions · #semaglutide · 2024-02-09u100_pati would hold27 reactions · #dosing-titration · 2024-02-05noct.titratehow do you tell a plateau from just being at your set point26 reactions · #dosing-titration · 2024-02-05noct.titratedoes a missed week reset anything or do you just carry on26 reactions · #dosing-titration · 2024-02-05deadspaceunrelated but changed my mind about needing 15, i was chasing a number rather than an outcome, your mileage will differ25 reactions · #tirzepatide · 2024-02-01bea_reconstitutesi was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication25 reactions · #semaglutide · 2024-02-05
Busiest logs in this fortnight
#semaglutide · 2024-02-04sorry to jump in going slow cost me nothing except time and saved me two bad weeks, thats my whole…27 msgs#semaglutide · 2024-02-09give it four weeks24 msgs#vendor-talk · 2024-02-01ask for a cold pack23 msgs#dosing-titration · 2024-02-05whats the longest anyone has stayed on one dose19 msgs#tirzepatide · 2024-02-08anyone got a 2.5 recon they like for the 2 vials19 msgs#dosing-titration · 2024-02-03if you are going up because the scale stalled for two weeks, wait. two weeks is noise, for what its worth…18 msgs#semaglutide · 2024-02-05not the same trial18 msgs#test-results · 2024-02-10my sheet has 5 lots from SGN with a spread under a point, which is tight18 msgs#side-effects · 2024-02-08what did your gallbladder symptoms actually feel like before it got diagnosed17 msgs#dosing-titration · 2024-02-06is there a point where going up stops buying you anything16 msgs#vendor-talk · 2024-02-04i keep three suppliers on rotation so a stock gap never becomes a problem15 msgs#tirzepatide · 2024-02-06went back to semaglutide after 19 months because the cost difference mattered more than the GI14 msgs