vialroom

#dosing-titration 2024-12-02

Monday39 messages8 participantstimes are UTC
Highlights from this day
  • void_volume — this is the single best argument for logging and it has nothing to do with data 21:33
  • lean_mass_lex — mine from 2024, and i deviated from it twice which is the point 21:48
  • blank_slate_bo — seeing the plan and the actual next to each other is the whole thing isnt it 21:51
  • void_volume — for anyone who wants the generic skeleton rather than a specific drug 22:48
QH

after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice

SD

appetite returning at the end of the week is extremely common and is not the dose failing

a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored, thats one data point

👀1⚠️5🤝1

pick a day and stick to it

two weeks is nothing

📉3❤️1
SD

if i took it 4 days late do i shift the schedule or go back to the old day

i log dose, day, weight and one line about how the week felt. thats enough to make decisions on

21:16pinned: write your ladder down before week one. the pinned unit explainer is directly above this
BS

is there any point planning a ladder in advance if youre going to change it anyway

LM

if you never wrote a plan down, every escalation feels reasonable in the moment

VV

this is the single best argument for logging and it has nothing to do with data

13
RR

mine was three columns. planned dose, actual dose, and one word about how the week went

the one word column turned out to be the useful one

LM

mine from 2024, and i deviated from it twice which is the point

PLAN (written before dose 1)
step 1  0.25mg   4 wks   escalate only if <=2 bad days/wk
step 2  0.5mg    4 wks   same rule
step 3  1.0mg    5 wks   review at 4, decide at 5
step 4  1.7mg    5 wks   hard stop and reassess here
step 5  2.4mg    open    only if slope has flattened 6+ wks

ACTUAL
step 1  0.25mg   4 wks   fine
step 2  0.5mg    6 wks   held, week 5 was rough
step 3  1.0mg    9 wks   held twice, losing well, no reason to move
step 4  1.7mg    ongoing 14 months, never went to 2.4
BS

seeing the plan and the actual next to each other is the whole thing isnt it

🙏11📌6
LM

yes. and the deviations were both downward in speed, which surprised me

VV

thats the usual direction for people who write a plan. the people who dont write one deviate upward

VV

nice sounding. i cannot prove it from this archive and i should not have said it as flatly as i did

LM

i needed a number, so i picked one. its arbitrary and it worked because it was written down

TE

which is more honest than most protocols people post in here

VV

for anyone who wants the generic skeleton rather than a specific drug

ElementWhat to decide up frontWhy
Step lengthminimum weeks per dosestops you reacting to one bad week
Escalation triggera symptom threshold, not a datemakes the decision reviewable
Review pointa week before the step endsgives you time to hold instead
Hard stopa dose you will not pass without a rethinkthe only real brake most people have
Exit planwhat coming down looks likealmost nobody writes this one
RR

template version of mine, blanked out. steal it

ladder-plan-vs-actual.csv
22 rows · 3 KB · not retained in the public archive
VV

and you didnt, because you had to write it down. thats the entire mechanism