Channel stats, last 30 days: 34 messages from 47 members.
#dosing-titration 2024-12-03
Tuesday31 messages6 participantstimes are UTC
Highlights from this day
- gall_bladder_gav — if the current dose is still working, going up is spending headroom you might want later 09:50
- gall_bladder_gav — stepping back down on purpose is a completely reasonable move and this channel should say so more often, ymmv 09:51
- meniscus_mel — my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step, not advice obviously 12:49
holding is not failing. most people here who lasted two years held at least one dose for months
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if you are asking whether to go up, the fact you are asking usually means not yet
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
if the current dose is still working, going up is spending headroom you might want later
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stepping back down on purpose is a completely reasonable move and this channel should say so more often, ymmv
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held for months
how much does the last dose still matter 6 days later
whats the smallest step anyone has managed between doses
whats the longest anyone has stayed on one dose
does a missed week reset anything or do you just carry on
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
*week 4 not week 5
how do you tell a plateau from just being at your set point
came down from a treatment dose to maintenance over about three months and it was uneventful, i could be wrong
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
not advice
Reminder set. I will post here in 4 days.
update on the earlier thing is there a point where going up stops buying you anything
quick one small steps are better than big ones and the only reason people take big ones is impatience, ill dig out the number
steady state is 5 weeks
you do not have to escalate at all. that is a real option that gets forgotten
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
thats noise
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step, not advice obviously
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
i hold for two months minimum before i decide a dose has stopped doing anything, happy to be corrected
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go slower
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
is there any actual reason to escalate every 4 weeks other than the trial did it
i hold for two months minimum before i decide a dose has stopped doing anything
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess