#oral-glp1 2026-06-05

Friday40 messages9 participantstimes are UTC

Highlights from this day

myrrh_measures — anyone switched from injectable to oral and kept the same effect 22:34
panel_before_after — my weekly log on oral is noisier than my injectable log ever was, same scales same mornings 22:54
retention_time — i do 6am with water and eat at 7, thats been my routine for 26 months 23:02
monoisotopic — coffee is not plain water. i tried it for a month and my results got worse 23:15
tallinn_taper — is the absorption variability why the oral doses look so high orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ 23:18

rezept_rolf 22:30

whats the bioavailability actually like, i keep seeing about one percent

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did anyone get consistent results on the oral or is it always patchy

myrrh_measures 22:34

anyone switched from injectable to oral and kept the same effect

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evidence_or_not 22:36

tea also does not count, in case anyone was hoping

lost 38kg over 18 months on oral, slower than my injectable stretch, i stuck with it anyway

evidence_or_not tea also does not count, in case anyone was hoping

myrrh_measures 22:40

my oral results were inconsistent week to week and i eventually decided it was me, not the tablet

did OASIS use the same fasting conditions as the earlier work

verify_or_dont 22:43

the fasting window is the difference between a dose and a very expensive tablet
splitting a dose made the absorption problem worse rather than better in my own log

ruined my breakfast

mine was patchy too

oral was easier on my gut than injecting at what felt like a similar effect, which surprised me

tallinn_taper 22:50

about one percent

fasted every morning

evidence_or_not lost 38kg over 18 months on oral, slower than my injectable stretch, i stuck with it…

panel_before_after 22:54

my weekly log on oral is noisier than my injectable log ever was, same scales same mornings

Cited study

Oral Semaglutide 50 mg in Adults with Overweight or Obesity (OASIS 1)

The Lancet · 2023

The high-dose oral. Absorption rules matter enormously here.

verify_or_dont 22:56

SNAC does the work

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panel_before_after 22:58

not a peptide

i keep the tablet by the kettle so i take it before i think about food

retention_time 23:02

i do 6am with water and eat at 7, thats been my routine for 26 months

fridge-temps.csv

143 rows · not retained in the public archive

verify_or_dont 23:04

roughly one percent gets absorbed, which is why the tablet strength looks nothing like an injectable dose

plain water only

retention_time 23:07

the 30 minutes starts when you swallow it, and i set a timer because i cannot be trusted

tallinn_taper 23:09

PIONEER or OASIS, which one was the higher dose oral

verify_or_dont plain water only

monoisotopiclab23:11

is the plain water rule actually load bearing or is it a formality

tallinn_taper 23:13

the oral disappointed me on the mornings i couldnt manage 30 minutes fasted, which was most of them, ill dig out the number

monoisotopiclab23:15

coffee is not plain water. i tried it for a month and my results got worse

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tallinn_taper 23:17

thirty minutes, no cheating

is the absorption variability why the oral doses look so high
orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ

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retention_time 23:20

did anyone go back to injecting after trying oral

orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ, not advice obviously

big mg small dose

OASIS ran under the same sort of fasting conditions, thats not the variable between the two

technique probably

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is there any point splitting an oral dose

set a timer

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the oral mg number is bigger because almost none of it gets in, thats the entire reason