unrelated but SNAC raises the local pH and protects it long enough to cross, thats its whole job
#oral-glp1 2026-06-06
- auckland_aliquot — PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses 15:39
- auckland_aliquot — splitting a dose made the absorption problem worse rather than better in my own log 16:03
- VialBot — Batch lookup C-4402: 4 independent reports on file, earliest 2026-02-25. 16:06
one percent is the number people quote and the spread around it is the actual story
tea also does not count, in case anyone was hoping, thats just me
not a peptide
is orforglipron a peptide at all
PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses
big mg small dose
coffee doesnt count
does coffee count as plain water, asking for obvious reasons
splitting a dose made the absorption problem worse rather than better in my own log
Batch lookup C-4402: 4 independent reports on file, earliest 2026-02-25.
anyone switched from injectable to oral and kept the same effect
SNAC does the work
PIONEER or OASIS, which one was the higher dose oral
genuine question did OASIS use the same fasting conditions as the earlier work
absorption is the variable, not the molecule. same tablet, different morning, different result
took 16 weeks before i saw anything on oral, roughly twice what the injection took me
genuine question i was wrong about the water amount, i was using a sip and it needs a lot more than that
orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ
is the non peptide thing why orforglipron doesnt need the fasting rules
technique probably
the oral mg number is bigger because almost none of it gets in, thats the entire reason
my weekly log on oral is noisier than my injectable log ever was, same scales same mornings
nobody should copy my morning routine, but the timer is the bit i would keep, for what its worth
ruined my breakfast
the inconsistency is mostly technique and admitting that took me about a year
plain water only, about half a glass, then nothing for 30 minutes. i follow it exactly
*VendorInvestigate not the other one