#reconstitution 2025-10-01

Wednesday37 messages8 participantstimes are UTC

Highlights from this day

unsolicited_dm — a slightly collapsed cake is cosmetic. a puddle in the bottom is not 19:51
unsolicited_dm — 10mg in 2ml is 5mg/ml. so 0.5mg is 0.1ml which is 10 units on a u100, someone check my working 20:14
no_appetite_nia — it should be completely clear with no floaters. cloudy means stop 21:52

unsolicited_dm 19:51

a slightly collapsed cake is cosmetic. a puddle in the bottom is not

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ferrous_ashmod19:57

whats the smallest volume you would trust yourself to measure on a u100

VialBotbot20:03

Batch lookup F-1330: 7 independent reports on file, earliest 2025-01-17.

ferrous_ashmod20:06

10mg in 1ml is 10mg/ml, so 2.5mg is 25 units. thats the one i use
15mg in 3ml is 5mg/ml. same numbers as 10 in 2, just more of it

ferrous_ashmod20:12

for the archive one unit is 0.01ml. 100 units is 1ml. everything else in this channel follows from that, ymmv

unsolicited_dm 20:14

10mg in 2ml is 5mg/ml. so 0.5mg is 0.1ml which is 10 units on a u100, someone check my working

U-100 syringe: 1 unit = 0.01 ml
  10u = 0.10 ml
  25u = 0.25 ml
  50u = 0.50 ml
 100u = 1.00 ml
mg drawn = ml drawn x mg/ml

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unsolicited_dm 20:21

do not add more bac water to an already reconstituted vial, you have lost track of the concentration

benzyl alcohol is what makes it bacteriostatic. it is about 0.9% typically

no_appetite_nia 20:23

20mg in 2ml is 10mg/ml. 1mg is 10 units, 2mg is 20 units, easy

[edited]

no_appetite_nia 20:30

i keep a spare vial of bac water in the fridge purely so i never rush the maths

swirl dont shake

U-100 syringe: 1 unit = 0.01 ml
  10u = 0.10 ml
  25u = 0.25 ml
  50u = 0.50 ml
 100u = 1.00 ml
mg drawn = ml drawn x mg/ml

no_appetite_nia 20:42

is a slightly cloudy solution ever ok or is that always a bin it

does temperature of the bac water matter at all

bench_notes 20:51

my vial pulled the water in on its own, is that the vacuum or did i do something

took me a year to stop over-diluting. the measurement error at 4 units is worse than the convenience

VialBotbot20:57

Reminder set. I will post here in 2 days.

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lead_time_lars 21:05

thats fine

lead_time_lars 21:13

swirl it. do not shake it. the foam is denatured protein and you are not getting it back

temperature of the diluent does not matter. how fast you push it in does

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bench_notes 21:18

why does everyone say 2ml specifically and not 1ml

batch_bandit 21:19

label the vial

coming back after 6 months, has the pinned recon volume advice changed

the meniscus thing is real. read it at eye level or you are guessing by a unit either way

bench_notes 21:34

bacteriostatic water for anything multi-use. sterile water has no preservative in it at all, your mileage will differ

unsolicited_dm do not add more bac water to an already reconstituted vial, you have lost track of the…

bench_notes 21:45

is it worth buying a 3ml syringe for the diluent or is the insulin one fine

quick one give it 8 minutes at room temperature before you decide it has not dissolved

dead space

you can absolutely just always use 2ml, and honestly most of us should

no_appetite_nia 21:52

it should be completely clear with no floaters. cloudy means stop

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unsolicited_dm 21:53

yep 10 units

step_one_sian 21:56

i write the mg/ml on the vial with a sharpie the moment i reconstitute it

unsolicited_dm 22:16

is there any reason not to just always use 2ml

no_appetite_nia 22:17

pick the volume so your dose is a whole number of units. thats the entire trick

*that should say weekly

unsolicited_dm 22:19

30mg in 3ml is 10mg/ml, so 5mg is 50 units. half the barrel, feels like a lot but its right, not advice obviously

not sterile water

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batch_bandit 22:22

i was wrong about this last year: it is fine to draw cold, it just stings more going in