#retatrutide 2025-01-27

research use only is on every vial and i treat it as exactly that, nobody here is prescribing

there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists

lost 34kg over 26 months at doses well under what the trials used

i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind

phase 2 was still trending at the end which is why the phase 3 readout matters more than usual

did the phase 2 plateau or was it still moving at the end

the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial

back after 14 months, has anything actually been published since

settled by month three

the purity spread across lots worries me more than the molecule does

low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom

update on the earlier thing anyone gone above 15 and what changed

the half life supports weekly dosing and thats what ive done from the start

anyone compared their VendorInvestigate purity across two different BCH lots

triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history

whats a sensible starting point, im seeing everything from 0.5 to 2

anyone logging resting heart rate on this

while im here anyone tracking blood pressure alongside the heart rate

the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me

did the phase 2 result actually come in higher than the tirzepatide numbers

how do people square the research use only framing with logging their own use

low and slow

is TRIUMPH the phase 3 programme

i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps

im at 12 and the appetite effect is stronger than i expected, normal

energy expenditure isnt something i could feel, though my sleep tracker disagreed with me

stepping in 7.5 increments instead of doubling is the only thing i would change if i started again

people insist on small steps because the side effects arrive faster than on the other two