nobody should read my log as a plan, im recording what i did and thats all it is, we shall see
#retatrutide 2026-01-12
Monday58 messages13 participantstimes are UTC
Highlights from this day
- otto_swirls — the honest position is this has less human evidence behind it than anything else discussed here, not advice obviously 14:11
- ring_size_down — blood pressure stayed flat for me while heart rate moved, which i didnt expect 14:30
- typosquat_tay — there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists 20:48
anyone logging resting heart rate on this
i said 9 months ago that my heart rate had settled and it has stayed settled since, happy to be corrected
no long term data
mine went up too
appetite suppression at 0.25 was stronger than my tirzepatide experience at a comparable point
the honest position is this has less human evidence behind it than anything else discussed here, not advice obviously
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lost 33kg over 23 months at doses well under what the trials used
settled by month three
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the purity spread across lots worries me more than the molecule does, n of 1 obviously
glucagon is the new bit
blood pressure stayed flat for me while heart rate moved, which i didnt expect
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did the phase 2 plateau or was it still moving at the end
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
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triple agonist yeah
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
anyone tracking blood pressure alongside the heart rate
[edited]my resting rate went up 5 bpm in the first month and came back most of the way by month 14
stepping in 2.5 increments instead of doubling is the only thing i would change if i started again
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule, someone check my working
New independent result logged — QST, lot F-1330, purity 98.6% (Janoshik).
triple agonist meaning GLP-1, GIP and glucagon, have i got that right
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buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
reconstituted the 2 vial to 2mg/ml specifically so i could take 2 without measuring crumbs
cant feel it honestly
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energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
smaller steps here
[edited]TRIUMPH is phase 3
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
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the half life supports weekly dosing and thats what ive done from the start
im at 2.5 and the appetite effect is stronger than i expected, normal
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
while im here is TRIUMPH the phase 3 programme
phase 2 only
back after 22 months, has anything actually been published since
does the energy expenditure claim show up as anything you can feel
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i log resting heart rate every morning because of this and its the one number i actually watch
[edited]held mine ages
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)whats the half life like, is it weekly the same way
no idea whether the heart rate settles for everyone, mine did and one log isnt data
research use only
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
low and slow
sat at 7.5 for 9 months rather than climbing and it kept working, so i never went up
logging rhr daily
is the GI worse than tirzepatide or about the same
ok so reconstituted the 30 vial to 4mg/ml specifically so i could take 2.5 without measuring crumbs
my resting heart rate is up about 6 bpm, did that settle for anyone
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came off at 26 weeks because my resting rate stayed elevated and i didnt like it
TRIUMPH is phase 3
how do people square the research use only framing with logging their own use
my resting rate went up 8 bpm in the first month and came back most of the way by month 22
is the glucagon arm what people mean by the energy expenditure thing
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slightly off topic but i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
how long before people saw the first change at 5
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
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phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
the purity spread across lots worries me more than the molecule does
did the phase 2 result actually come in higher than the tirzepatide numbers
anyone gone above 12 and what changed
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did anyone come off because of the heart rate