i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind, ymmv
#retatrutide 2026-03-24
Tuesday57 messages13 participantstimes are UTC
Highlights from this day
- non_scale_win — anyone stayed at 1.7 for months rather than climbing 17:39
- two_lifts_a_week — coming back to this whats a sensible starting point, im seeing everything from 0.5 to 2 18:35
- cross_border_cam — energy expenditure isnt something i could feel, though my sleep tracker disagreed with me 19:02
- mg_per_ml — the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial 19:58
held mine ages
🧊9👍1
glucagon is the new bit
📈3🧊1✅12
*PeptideMeter not the other one
my resting rate went up 3 bpm in the first month and came back most of the way by month 26
😂11
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
people insist on small steps because the side effects arrive faster than on the other two
Medutest came back 99.2 on one lot and 96.8 on the next from the same MKM, both fine
anyone stayed at 1.7 for months rather than climbing
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)😂3✅9💀3
logging rhr daily
[edited]did the phase 2 plateau or was it still moving at the end
*Medutest not the other one
phase 2 only
settled by month three
is the GI worse than tirzepatide or about the same
unrelated but my resting heart rate is up about 8 bpm, did that settle for anyone
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
stopped for 12 months and restarted at half my old dose, the ramp was easier second time
😂9👀5
watching my heart rate
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
📉9
smaller steps here
held at 1.7 for 5 months and it never plateaued for me, which i cant explain, i have it written down somewhere
coming back to this whats a sensible starting point, im seeing everything from 0.5 to 2
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)quick one i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
📈8🧪2
how slow is low and slow here, four weeks a step or longer
lot-log.csv
574 rows · not retained in the public archive
the purity spread across lots worries me more than the molecule does
i said 3 months ago that my heart rate had settled and it has stayed settled since
i said 9 months ago that my heart rate had settled and it has stayed settled since
stepping in 0.25 increments instead of doubling is the only thing i would change if i started again
🎉1⚠️6
back_from_awaystopped for 12 months and restarted at half my old dose, the ramp was easier second time
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
🧊17💀9⚠️16
buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
anyone reconstituting 10 vials to 10 so the steps come out smaller
🧊5
whats the half life like, is it weekly the same way
😂4
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
appetite suppression at 2.4 was stronger than my tirzepatide experience at a comparable point
two_lifts_a_weekcoming back to this whats a sensible starting point, im seeing everything from 0.5 to 2
reconstituted the 20 vial to 8mg/ml specifically so i could take 15 without measuring crumbs
cant feel it honestly
blood pressure stayed flat for me while heart rate moved, which i didnt expect
[edited]back after 17 months, has anything actually been published since
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
👀1🤝8
the honest position is this has less human evidence behind it than anything else discussed here
anyone tracking blood pressure alongside the heart rate
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
✅1⚠️17🤝6
low and slow
Assay note: ERP lot C-4402 reported at 96.8% of label content.
does the energy expenditure claim show up as anything you can feel
sat at 15 for 7 months rather than climbing and it kept working, so i never went up
TRIUMPH is phase 3
❤️12⚠️12🧪10
did the phase 2 result actually come in higher than the tirzepatide numbers
genuine question triple agonist meaning GLP-1, GIP and glucagon, have i got that right
update on the earlier thing research use only is on every vial and i treat it as exactly that, nobody here is prescribing
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
chromatogram-overlay.png
1240 × 720 · 826 KB · not retained in the public archive
lost 30kg over 11 months at doses well under what the trials used
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
is the phase 2 dosing anywhere near what people here run
mine went up too
GI was about the same as tirzepatide for me, the difference was how fast it arrived, i have it written down somewhere
the heart rate thing is real enough that i mention it whenever someone asks about starting
the half life supports weekly dosing and thats what ive done from the start
people insist on small steps because the side effects arrive faster than on the other two