is there any long term safety data at all or is it phase 2 and hope
#retatrutide 2026-04-30
Thursday63 messages11 participantstimes are UTC
Highlights from this day
- vik_verifies — triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history 15:06
- week_three_wall — phase 2 was still trending at the end which is why the phase 3 readout matters more than usual 16:17
- batch_bandit — the heart rate thing is real enough that i mention it whenever someone asks about starting 16:38
- triumph_watch — anyone compared their Medutest purity across two different ERP lots low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom 20:39
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
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lost 24kg over 1 months at doses well under what the trials used
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GI was about the same as tirzepatide for me, the difference was how fast it arrived
TRIUMPH is phase 3
anyone stayed at 0.5 for months rather than climbing
smaller steps here
my resting rate went up 5 bpm in the first month and came back most of the way by month 9
watching my heart rate
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held at 0.25 for 26 months and it never plateaued for me, which i cant explain
phase 2 only
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i log resting heart rate every morning because of this and its the one number i actually watch
held mine ages
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
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how do people square the research use only framing with logging their own use
glucagon is the new bit
no idea whether the heart rate settles for everyone, mine did and one log isnt data
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)triple agonist yeah
buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
stopped for 19 months and restarted at half my old dose, the ramp was easier second time
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
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logging rhr daily
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
reconstituted the 15 vial to 2.5mg/ml specifically so i could take 15 without measuring crumbs
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i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
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the heart rate thing is real enough that i mention it whenever someone asks about starting
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cant feel it honestly
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial, n of 1 obviously
the honest position is this has less human evidence behind it than anything else discussed here
for the archive does the glucagon arm explain the heart rate or is that unrelated
[edited]how slow is low and slow here, four weeks a step or longer
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there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)nobody should read my log as a plan, im recording what i did and thats all it is, i have it written down somewhere
did anyone come off because of the heart rate
no long term data
appetite suppression at 2.4 was stronger than my tirzepatide experience at a comparable point, thats one data point
mine went up too
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps, ymmv
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
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is the phase 2 dosing anywhere near what people here run
no idea whether the heart rate settles for everyone, mine did and one log isnt data
sat at 0.5 for 6 months rather than climbing and it kept working, so i never went up
the half life supports weekly dosing and thats what ive done from the start, thats just me
research use only
the purity spread across lots worries me more than the molecule does
how long before people saw the first change at 10
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cant feel it honestly
sharps_bin_sidi went up too fast, got a fortnight of nothing but nausea, and dropped back two steps,…
right so blood pressure stayed flat for me while heart rate moved, which i didnt expect
did the phase 2 result actually come in higher than the tirzepatide numbers
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settled by month three
low and slow
back after 26 months, has anything actually been published since
appetite suppression at 0.5 was stronger than my tirzepatide experience at a comparable point
anyone reconstituting 5 vials to 10 so the steps come out smaller
whats a sensible starting point, im seeing everything from 0.5 to 2
for the archive TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
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energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
triple agonist yeah
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
sorry to jump in stepping in 5 increments instead of doubling is the only thing i would change if i started again
anyone tracking blood pressure alongside the heart rate
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anyone compared their Medutest purity across two different ERP lots
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
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i said 4 months ago that my heart rate had settled and it has stayed settled since
the purity spread across lots worries me more than the molecule does
came off at 25 weeks because my resting rate stayed elevated and i didnt like it