phase 2 only
#retatrutide 2026-05-02
Saturday34 messages7 participantstimes are UTC
Highlights from this day
- gradient_greg — low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom, ask me again in a month 18:04
- noct.titrate — quick one buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely 18:30
- gradient_greg — reconstituted the 30 vial to 10mg/ml specifically so i could take 1.7 without measuring crumbs, ill dig out the number 18:47
- VialBot — Inter-lab diff for lot B-0114: 98.6% vs 98.1%. Within expected range. 19:18
- non_scale_win — stepping in 7.5 increments instead of doubling is the only thing i would change if i started again 19:54
sat at 12 for 6 months rather than climbing and it kept working, so i never went up
appetite suppression at 15 was stronger than my tirzepatide experience at a comparable point
smaller steps here
🤝2
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom, ask me again in a month
held at 15 for 14 months and it never plateaued for me, which i cant explain
triple agonist yeah
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
quick one buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
came off at 14 weeks because my resting rate stayed elevated and i didnt like it
TRIUMPH is phase 3
reconstituted the 30 vial to 10mg/ml specifically so i could take 1.7 without measuring crumbs, ill dig out the number
genuine question blood pressure stayed flat for me while heart rate moved, which i didnt expect
back after 24 months, has anything actually been published since
Inter-lab diff for lot B-0114: 98.6% vs 98.1%. Within expected range.
held mine ages
the purity spread across lots worries me more than the molecule does
stepping in 7.5 increments instead of doubling is the only thing i would change if i started again
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the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial, we shall see
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
while im here the honest position is this has less human evidence behind it than anything else discussed here
glucagon is the new bit
🙏15😂2📈1
how slow is low and slow here, four weeks a step or longer
anyone tracking blood pressure alongside the heart rate
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
no long term data
right so did anyone come off because of the heart rate
my resting rate went up 5 bpm in the first month and came back most of the way by month 24
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
settled by month three
mine went up too
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
the heart rate thing is real enough that i mention it whenever someone asks about starting
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